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索磷布韦给药及其撤药对成年雄性白化大鼠下颌下唾液腺的影响：一项组织学和超微结构研究

Effect of Sofosbuvir Administration and Its Withdrawal on the Submandibular Salivary Gland of Adult Male Albino Rats: A Histological and Ultra-Structural Study.

作者信息

Abdeen Asmaa Mahmoud, Essawy Tarik, Mohammed Saher Sayed

机构信息

Oral Biology Department, Faculty of Dentistry, MINIA University, Minia, Egypt.

Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

出版信息

Open Access Maced J Med Sci. 2019 Dec 10;7(23):4101-4109. doi: 10.3889/oamjms.2019.868. eCollection 2019 Dec 15.

DOI:10.3889/oamjms.2019.868
PMID:32165960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7061369/
Abstract

BACKGROUND

Sofosbuvir (SOF) was approved in 2013 as a part of first-line treatment for hepatitis C virus (HCV); it has activity against all genotypes with extrahepatic adverse effects have recently arisen.

AIM

Investigating sofosbuvir-induced alterations in the rat submandibular salivary gland (SMSG).

METHODS

A group of 80 adult albino rats weighing about ± 150 gm were used in the experiment. The rats were divided into 3 groups: Group I (control group) received distilled water, Group II (experimental group) divided into 2 subgroups and received SOF 40 mg/kg/day dissolved in distilled water for 1 and 3 months and Group III (recovery group) allowed for 1 month of recovery after SOF withdrawal. All animals were sacrificed; the SMSG was dissected, and specimens were examined histologically and ultra-structurally.

RESULTS

Compared to Group I, Group II subgroup (1) showed acinar and ductal vacuolisation, discontinuity of the epithelial lining associated with retained secretion and congested blood vessels. These changes were found to be exaggerated in the subgroup (2) accompanied by acinar and ductal shrinkage, interstitial oedema, haemorrhage, chronic inflammatory cells infiltration and loss of gland compactness. Amelioration of the histological changes was detected in Group III after SOF withdrawal. The ultrastructural examination confirmed these histological results.

CONCLUSION

SOF had induced apparent alterations in the structure and ultrastructure of SMSG. The SOF-induced alterations were time-dependent, attributed mainly to mitochondrial toxicity and partially ameliorated by its withdrawal.

摘要

背景

索磷布韦（SOF）于2013年被批准作为丙型肝炎病毒（HCV）一线治疗的一部分；它对所有基因型均有活性，最近出现了肝外不良反应。

目的

研究索磷布韦对大鼠下颌下唾液腺（SMSG）的影响。

方法

实验使用80只体重约±150克的成年白化大鼠。大鼠分为3组：第一组（对照组）给予蒸馏水，第二组（实验组）分为2个亚组，分别给予溶解于蒸馏水中的索磷布韦40毫克/千克/天，持续1个月和3个月，第三组（恢复组）在停用索磷布韦后给予1个月的恢复期。所有动物均处死后，解剖SMSG，对标本进行组织学和超微结构检查。

结果

与第一组相比，第二组亚组（1）显示腺泡和导管空泡化、上皮衬里连续性中断伴分泌物潴留和血管充血。在亚组（2）中发现这些变化更为明显，伴有腺泡和导管萎缩、间质水肿、出血、慢性炎症细胞浸润和腺体致密性丧失。停用索磷布韦后，第三组的组织学变化有所改善。超微结构检查证实了这些组织学结果。

结论

索磷布韦可引起SMSG结构和超微结构的明显改变。索磷布韦引起的改变具有时间依赖性，主要归因于线粒体毒性，停药后可部分改善。

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3
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4
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5
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