Savoie T M, Emory E K, Moody-Thomas S
Department of Psychology, Emory University, Atlanta, Georgia 30322.
J Stud Alcohol. 1988 Sep;49(5):430-5. doi: 10.15288/jsa.1988.49.430.
Alcohol pharmacokinetics, mood-state alterations and psychomotor performance were investigated in women and men at risk for developing alcoholism. Estimated body water was used to calculate the alcohol dose in an effort to eliminate differences in alcohol pharmacokinetics between women and men due to differences in body composition. Differences were not detected between women and men or family history groups (family history positive, FH +, and family history negative, FH-) on absorption time, peak blood alcohol level (BAL), elimination time, or area under the blood alcohol curve (AUC). FH + men reported no central stimulant effects at peak BAL on the Sensation Scale, whereas FH- men and women all reported central stimulant effects. Further, FH + men reported a decrease in anxiety after the ingestion of alcohol. Acute intoxication did not affect performance in the FH + group on a finger-tapping task. In the FH - group, the dominant hand was significantly impaired during the ascending limb of the blood alcohol curve and recovered during the descending limb. Differences between family history groups or sex were not detected on a grooved-pegboard task. Results indicated that FH + men may experience alcohol differently from the FH - group and FH + women. FH + women also showed different reactions to acute alcohol than the FH - group. However, these differences were not as consistent across tasks.
对有酗酒风险的女性和男性的酒精药代动力学、情绪状态改变及精神运动表现进行了研究。使用估计的身体水分来计算酒精剂量，以消除由于身体组成差异导致的男女酒精药代动力学差异。在吸收时间、血中酒精峰值水平（BAL）、消除时间或血中酒精曲线下面积（AUC）方面，未检测到女性与男性或家族史组（家族史阳性，FH +，和家族史阴性，FH -）之间存在差异。FH +男性在BAL峰值时在感觉量表上未报告中枢兴奋作用，而FH -男性和女性均报告有中枢兴奋作用。此外，FH +男性报告饮酒后焦虑感降低。急性中毒对FH +组的手指敲击任务表现没有影响。在FH -组中，优势手在血中酒精曲线上升阶段明显受损，在下降阶段恢复。在有槽钉板任务中未检测到家族史组或性别之间的差异。结果表明，FH +男性对酒精的体验可能与FH -组和FH +女性不同。FH +女性对急性酒精的反应也与FH -组不同。然而，这些差异在不同任务中并不一致。
