载多柔比星的超声响应型高生物相容性纳米液滴用于肿瘤成像和治疗。
Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment .
机构信息
Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, China.
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, Qilu Hospital of Shandong University, Jinan, China.
出版信息
Drug Deliv. 2020 Dec;27(1):469-481. doi: 10.1080/10717544.2020.1739170.
As an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) . The experimental results showed that the BCNDs were successfully prepared with high biosafety and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic.
作为一种可注射的抗癌药物输送系统，纳米载体的生物安全性是其临床应用的最重要前提。我们的研究目的是合成特殊的超声响应型高生物相容性壳聚糖纳米液滴（BCNDs），观察它们时空控制阿霉素（DOX）的递送。实验结果表明，成功制备了具有高生物安全性和出色超声成像能力的 BCNDs。DOX-BCNDs 增强了 DOX 的抗癌作用并抑制了肿瘤的发展。它们还降低了对心脏和肾脏的副作用。总之，BCNDs 是一种新型的智能纳米载体，具有高生物相容性和疗效，有望在临床上得到应用。
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