University of Health Sciences Turkey, Beyoğlu Eye Training and Research Hospital, Clinic of Ophthalmology, İstanbul, Turkey
İstanbul Medipol University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey
Turk J Ophthalmol. 2020 Mar 5;50(1):20-25. doi: 10.4274/tjo.galenos.2019.51460.
To investigate the effect of cycloplegia on anterior segment structures in keratoconus and forme fruste keratoconus patients using corneal topography.
In this study, 40 patients with keratoconus (group 1), 40 patients with forme fruste keratoconus (group 2), and 40 healthy subjects (group 3) were evaluated prospectively. Flat keratometry (K) value (K1), steep K value (K2), mean K value (Kmean), maximum K value (Kmax), corneal astigmatism value, anterior chamber depth (ACD), symmetry index front, symmetry index back, thinnest corneal thickness, central corneal thickness and corneal volume were measured using Sirius topography before and after cycloplegia. Results were compared with one way ANOVA test.
The mean age of the participants was 24.4±6.2 years for group 1, 26.3±4.3 years for group 2 and 26.5±6.1 years for group 3. There was no difference between the groups with respect to mean age and gender (p>0.05). Mean K1 value was 45.54±2.43 diopters (D) before cycloplegia and 45.46±2.48 D after cycloplegia for group 1 (p=0.044). K1 value didn’t change significantly after cycloplegia for group 2 and 3 (p=0.275, p=0.371). There was no significant difference in K2 and Kmean values after cycloplegia for all groups (p>0.05). Kmax value decreased significantly after cycloplegia in group 1 (p=0.001), but the difference was not significant for group 2 and 3 (p=0.087, p=0.241). ACD increased significantly after cycloplegia in all groups (p=0.001).
Cycloplegia causes corneal flattening only in manifest keratoconus patients, leading to an increase in ACD in all groups.
使用角膜地形图研究睫状肌麻痹对圆锥角膜和亚临床圆锥角膜患者眼前节结构的影响。
本研究前瞻性评估了 40 例圆锥角膜患者（第 1 组）、40 例亚临床圆锥角膜患者（第 2 组）和 40 例健康受试者（第 3 组）。在睫状肌麻痹前后，使用 Sirius 地形图测量平 K 值（K1）、陡 K 值（K2）、平均 K 值（Kmean）、最大 K 值（Kmax）、角膜散光值、前房深度（ACD）、前房对称指数、后房对称指数、最薄角膜厚度、中央角膜厚度和角膜容积。采用单因素方差分析比较结果。
第 1 组、第 2 组和第 3 组参与者的平均年龄分别为 24.4±6.2 岁、26.3±4.3 岁和 26.5±6.1 岁。各组间年龄和性别无差异（p>0.05）。第 1 组睫状肌麻痹前的平均 K1 值为 45.54±2.43 屈光度（D），睫状肌麻痹后的 K1 值为 45.46±2.48 D（p=0.044）。第 2 组和第 3 组睫状肌麻痹后 K1 值无明显变化（p=0.275，p=0.371）。所有组睫状肌麻痹后 K2 和 Kmean 值无显著差异（p>0.05）。第 1 组睫状肌麻痹后 Kmax 值显著降低（p=0.001），但第 2 组和第 3 组无显著差异（p=0.087，p=0.241）。所有组睫状肌麻痹后 ACD 均显著增加（p=0.001）。
睫状肌麻痹仅使显性圆锥角膜患者的角膜变平，导致所有组的 ACD 增加。
