PSL Université Paris, Chimie ParisTech - CNRS, Institute of Chemistry for Life and Health Sciences (i-CLeHS), 11 rue Pierre et Marie Curie, 75005, Paris, France.
Org Lett. 2020 Apr 3;22(7):2681-2686. doi: 10.1021/acs.orglett.0c00638. Epub 2020 Mar 13.
A novel and efficient access to polyfunctionnalized chiral 1-tetralols, bearing two contiguous quaternary carbon stereocenters, has been developed from various and easily accessible alkynyl-1,3-diketones, through a cascade process including a regioselective alkyne insertion, a 1,4-Rh shift, and a nucleophilic addition step via the desymmetrization of the 1,3-diketone moiety thanks to an appropriate rhodium-chiral diene complex in the presence of arylboronic acids.
一种新颖高效的方法，可从各种易得的炔基-1,3-二酮出发，制备具有两个毗邻的季碳手性中心的多官能化手性 1-四醇，该方法包括级联反应过程，其中包括炔烃的区域选择性插入、1,4-Rh 迁移以及通过 1,3-二酮部分的不对称去对称化，借助合适的铑-手性二烯配合物与芳基硼酸进行亲核加成反应。
