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小儿膀胱输尿管反流的手术治疗进展:开放性输尿管再植术仍为“金标准”吗?

Evolving surgical management of pediatric vesicoureteral reflux: is open ureteral reimplantation still the 'Gold Standard'?

机构信息

Emory University School of Medicine Children's Healthcare of Atlanta, Atlanta, GA 30328, USA.

Department of Urology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Int Braz J Urol. 2020 May-Jun;46(3):314-321. doi: 10.1590/S1677-5538.IBJU.2020.99.05.

Abstract

Vesicoureteral reflux, the retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urologic diagnoses in the pediatric population. Once detected, therapeutic options for urinary reflux are diverse, ranging from observation with or without continuous low-dose prophylactic antibiotics to a variety of operative interventions. While a standardized algorithm is lacking, it is generally accepted that management be tailored to individual patients based on various factors including age, likelihood of spontaneous resolution, risk of subsequent urinary tract infections with renal parenchymal injury, and parental preference. Anti-reflux surgery may be necessary in children with persistent reflux, renal scarring or recurrent pyelonephritis after optimization of bladder and bowel habits. Open, laparoscopic/robot-assisted and endoscopic approaches are all successful in correcting reflux and have been shown to reduce the incidence of febrile urinary tract infections.

摘要

膀胱输尿管反流是指尿液从膀胱逆流进入上尿路,是儿科人群中最常见的泌尿科诊断之一。一旦发现,治疗膀胱反流的方法多种多样,包括观察加或不加持续低剂量预防性抗生素,以及各种手术干预。虽然缺乏标准化的算法,但普遍认为,根据年龄、自发缓解的可能性、继发尿路感染伴肾实质损伤的风险以及家长的意愿等多种因素,应针对个体患者量身定制治疗方案。对于持续反流、肾瘢痕形成或膀胱和肠道习惯优化后反复出现肾盂肾炎的儿童,可能需要进行抗反流手术。开放手术、腹腔镜/机器人辅助和内镜方法均可成功纠正反流,并已被证明可降低发热性尿路感染的发生率。

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