艾滋病毒感染者的器官移植。
Organ transplantation in persons with HIV.
机构信息
Division of Infectious Diseases.
Divisions of Infectious Diseases and Organ Transplantation and Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
出版信息
AIDS. 2020 Jul 1;34(8):1107-1116. doi: 10.1097/QAD.0000000000002518.
: With current antiretroviral therapy, the lifespan of newly diagnosed persons with HIV (PWH) approaches that of uninfected persons. However, metabolic abnormalities related to both the disease and the virus itself, along with comorbidities of aging, have resulted in end-organ disease and organ failure as a major cause of morbidity and mortality. Solid organ transplantation is a life-saving therapy for PWH who have organ failure, and the approval of the HIV Organ Policy Equity Act has opened and expanded opportunities for PWH to donate and receive organs. The current environment of organ transplantation for PWH will be reviewed and future directions of research and treatment will be discussed.
: 目前的抗逆转录病毒疗法使新诊断出的 HIV 感染者（PWH）的预期寿命接近未感染者。然而，与疾病和病毒本身相关的代谢异常，以及与衰老有关的合并症，导致终末器官疾病和器官衰竭成为发病率和死亡率的主要原因。对于因器官衰竭而需要接受治疗的 PWH 来说，实体器官移植是一种挽救生命的疗法，而《HIV 器官政策公平法案》的批准为 PWH 提供了更多捐赠和接受器官的机会。本文将对目前 PWH 器官移植的环境进行审查，并探讨未来的研究和治疗方向。
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