M. Rupp, V. Alt, Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany.
E. Lau, Exponent Inc, Menlo Park, CA, USA.
Clin Orthop Relat Res. 2020 Jul;478(7):1622-1633. doi: 10.1097/CORR.0000000000001214.
Future projections for both TKA and THA in the United States and other countries forecast a further increase of already high numbers of joint replacements. The consensus is that in industrialized countries, this increase is driven by demographic changes with more elderly people being less willing to accept activity limitations. Unlike the United States, Germany and many other countries face a population decline driven by low fertility rates, longer life expectancy, and immigration rates that cannot compensate for population aging. Many developing countries are likely to follow that example in the short or medium term amid global aging. Due to growing healthcare expenditures in a declining and aging population with a smaller available work force, reliable predictions of procedure volume by age groups are requisite for health and fiscal policy makers to maintain high standards in arthroplasty for the future population.Questions/purposes (1) By how much is the usage of primary TKA and THA in Germany expected to increase from 2016 through 2040? (2) How is arthroplasty usage in Germany expected to vary as a function of patient age during this time span?
The annual number of primary TKAs and THAs were calculated based on population projections and estimates of future healthcare expenditures as a percent of the gross domestic product (GDP) in Germany. For this purpose, a Poisson regression analysis using age, gender, state, healthcare expenditure, and calendar year as covariates was performed. The dependent variable was the historical number of primary TKAs and THAs performed as compiled by the German federal office of statistics for the years 2005 through 2016.
Through 2040, the incidence rate for both TKA and THA will continue to increase annually. For TKA, the incidence rate is expected to increase from 245 TKAs per 100,000 inhabitants to 379 (297-484) (55%, 95% CI 21 to 98). The incidence rate of THAs is anticipated to increase from 338 to 437 (357-535) per 100,000 inhabitants (29% [95% CI 6 to 58]) between 2016 and 2040. The total number of TKAs is expected to increase by 45% (95% CI 14 to 8), from 168,772 procedures in 2016 to 244,714 (95% CI 191,920 to 312,551) in 2040. During the same period, the number of primary THAs is expected to increase by 23% (95% CI 0 to 50), from 229,726 to 282,034 (95% CI 230,473 to 345,228). Through 2040, the greatest increase in TKAs is predicted to occur in patients aged 40 to 69 years (40- to 49-year-old patients: 269% (95% CI 179 to 390); 50- to 59-year-old patients: 94% (95% CI 48 to 141); 60- to 69-year-old patients: 43% (95% CI 13 to 82). The largest increase in THAs is expected in the elderly (80- to 89-year-old patients (71% [95% CI 40 to 110]).
Although the total number of TKAs and THAs is projected to increase in Germany between now and 2040, the increase will be smaller than that previously forecast for the United States, due in large part to the German population decreasing over that time, while the American population increases. Much of the projected increase in Germany will be from the use of TKA in younger patients and from the use of THA in elderly patients. Knowledge of these trends may help planning by surgeons, hospitals, stakeholders, and policy makers in countries similar to Germany, where high incidence rates of arthroplasty, aging populations, and overall decreasing populations are present.
Level III, economic and decision analysis.
在美国和其他国家,未来全膝关节置换术(TKA)和全髋关节置换术(THA)的预测数量将进一步增加,目前已经处于较高水平。共识是,在工业化国家,这种增长是由人口结构变化驱动的,越来越多的老年人不太愿意接受活动限制。与美国不同,德国和许多其他国家面临着人口下降的局面,这是由低生育率、预期寿命延长和移民率造成的,而移民率无法弥补人口老龄化。在全球老龄化的背景下,许多发展中国家可能在短期内或中期也会出现这种情况。由于人口减少和老龄化,劳动力减少,医疗保健支出不断增加,因此需要对各年龄段的手术数量进行可靠预测,以便卫生和财政政策制定者能够为未来的人口维持关节置换术的高标准。问题/目的(1)到 2040 年,德国的初次 TKA 和初次 THA 的使用量预计将增加多少?(2)在此期间,德国的关节置换术使用量预计将如何随患者年龄而变化?
根据人口预测和未来医疗保健支出占国内生产总值(GDP)的百分比估计,计算了初次 TKA 和初次 THA 的年数量。为此,使用泊松回归分析,以年龄、性别、州、医疗保健支出和日历年作为协变量。因变量是德国联邦统计局为 2005 年至 2016 年期间汇编的初次 TKA 和初次 THA 的历史数量。
到 2040 年,TKA 和 THA 的发病率将继续每年增加。对于 TKA,预计发病率将从每 10 万人 245 例增加到 379 例(297-484)(55%,95%CI 21-98)。预计每 10 万人 THA 的发病率将从 338 例增加到 437 例(357-535)(29%[95%CI 6-58])。预计 2016 年至 2040 年间,TKA 的总数量将增加 45%(95%CI 14-8),从 2016 年的 168772 例增加到 2040 年的 244714 例(95%CI 191920-312551)。同期,初次 THA 的数量预计将增加 23%(95%CI 0-50),从 229726 例增加到 282034 例(95%CI 230473-345228)。到 2040 年,预计 40 至 69 岁患者的 TKA 数量增幅最大(40-49 岁患者:269%[95%CI 179-390];50-59 岁患者:94%[95%CI 48-141];60-69 岁患者:43%[95%CI 13-82])。THA 数量增幅最大的预计是老年人(80-89 岁患者:71%[95%CI 40-110])。
尽管预计到 2040 年,德国 TKA 和 THA 的总数将增加,但由于德国人口在此期间减少,而美国人口增加,因此增幅将小于此前对美国的预测。德国预计的大部分增长将来自年轻患者的 TKA 使用和老年患者的 THA 使用。了解这些趋势可能有助于德国等国家的外科医生、医院、利益相关者和政策制定者进行规划,这些国家的关节置换术发病率高、人口老龄化和总人口减少。
三级,经济和决策分析。