Kaplan H J, Streilein J W
J Immunol. 1978 Mar;120(3):689-93.
Exposure to alloantigen via the anterior chamber of the eye elicits a transient suppression of cellular immunity, whereas humoral immunity is preserved--i.e. F1 LI-ID. The majority of lymphoid cells inoculated into the anterior chamber are retained within the posterior segment of the eye. The latter serves as a depot of alloantigen, allowing the chronic egress of small numbers of cells into the vascular tree. The persistence of this antigen depot is essential to the development of F1 LI-ID. Since there is a preferential distribution of cells that migrate from the eye to the spleen, the functional integrity of the latter is also necessary to elicit F1 LI-ID. It is concluded that an anatomically intact spleen, i.v. presentation of antigen, and persistence of antigen within the eye are all important to the elicitation of this phenomenon.
经眼前房接触同种异体抗原会引发细胞免疫的短暂抑制，而体液免疫则得以保留——即F1 LI-ID。接种到前房的大多数淋巴细胞会滞留在眼后段。眼后段充当同种异体抗原的储存库，使少量细胞能够持续进入血管系统。这种抗原储存库的持续存在对于F1 LI-ID的发展至关重要。由于从眼迁移至脾脏的细胞存在优先分布，脾脏的功能完整性对于引发F1 LI-ID也是必要的。得出的结论是，解剖结构完整的脾脏、静脉内给予抗原以及抗原在眼内的持续存在对于引发这一现象均很重要。
