HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, 14080 Mexico City, Mexico.
Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 Mexico City, Mexico.
Cells. 2020 Mar 11;9(3):691. doi: 10.3390/cells9030691.
The pathogenesis of Rheumatoid Arthritis (RA) is not fully understood, probably influenced by genetic and environmental factors. Interstitial Lung Disease (ILD) is an extra-articular manifestation of RA, which contributes significantly to morbidity and mortality. The identification of anti-HLA antibodies has been useful in the transplantation field; however, its contribution to autoimmune diseases as RA has not been fully studied. We aimed to determine the presence of anti-HLA antibodies in RA patients with and without ILD and its possible association with clinical and biochemical markers. One-hundred and forty-seven RA patients, of which 65 had ILD (RA-ILD group), were included. Sera samples for Anti-HLA Class II LABScreen panel-reactive antibodies (PRA) were analyzed. In both groups, women predominated, and lung function was worse in patients with ILD. The anti-CCP+ (UI/mL) was higher in the RA group in comparison to RA-ILD ( < 0.001). Expositional risk factors (tobacco smoking and biomass-burning smoke) were higher in RA-ILD patients. PRA+ was identified in ~25% RA-ILD patients, while ~29% in the RA group. The CRP levels have a positive correlation with the percentage of reactivity (%PRA, = 0.02, r = 0.60) in the RA-ILD group. In conclusion, anti-HLA antibodies correlate with C-reactive protein levels in RA patients with ILD.
类风湿关节炎（RA）的发病机制尚未完全阐明，可能受遗传和环境因素的影响。间质性肺疾病（ILD）是 RA 的关节外表现，对发病率和死亡率有重要影响。抗 HLA 抗体的鉴定在移植领域很有用；然而，其对 RA 等自身免疫性疾病的贡献尚未得到充分研究。我们旨在确定有无间质性肺疾病的 RA 患者中存在抗 HLA 抗体及其与临床和生化标志物的可能相关性。共纳入 147 例 RA 患者，其中 65 例有间质性肺疾病（RA-ILD 组）。分析了抗 HLA Ⅱ类 LABScreen 面板反应性抗体（PRA）的血清样本。在两组中，女性均占多数，ILD 患者的肺功能更差。与 RA-ILD 相比，RA 组的抗 CCP+（UI/mL）更高（<0.001）。RA-ILD 患者中存在更多的暴露风险因素（吸烟和生物质燃烧烟雾）。约 25%的 RA-ILD 患者和 29%的 RA 组患者检测到 PRA+。RA-ILD 组的 CRP 水平与反应性百分比（%PRA，=0.02，r=0.60）呈正相关。总之，在有间质性肺疾病的 RA 患者中，抗 HLA 抗体与 C 反应蛋白水平相关。
