Jiang Hong, Can-Xin Xu, Pan Si-Jian, Na-Ying He, Sun Yu-Hao, Yan Fu-Hua, Bian Liu-Guan, Liu Chang, Sun Qing-Fang
Department of Neurosurgery, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Stereotactic and Functional Neurosurgery, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
J Neurol Sci. 2020 Jun 15;413:116769. doi: 10.1016/j.jns.2020.116769. Epub 2020 Mar 4.
Glucocorticoid (GC) is probably related to biological aging, but the exact mechanism remains unknown. Cushing's disease (CD) could represent a unique human model for examining the effects of prolonged exposure to hypercortisolism and its relationship with aging. Thus, we studied the alterations of neurites in CD patients with Neurite orientation dispersion and density imaging (NODDI).
CD patients (n = 15) and healthy control subjects (n = 15) were included in this study. Orientation dispersion index (Odi), neurite density index (Ndi), partial fraction of free water (f), partial fraction of extracellular water (f) were examined in a cross-sectional analysis.
Significant altered NODDI parameters were found in CD patients. Some of these alterations were correlated with current age. Additionally, increased dendritic density was found in cerebellar of CD patients.
Hypercortisolism relative reductions of the dendritic density were correlated with current age in several regions of CD patients. Our study enhances the understanding of the link between the aging and GC.
糖皮质激素（GC）可能与生物衰老有关，但其确切机制尚不清楚。库欣病（CD）可能是一种独特的人类模型，用于研究长期暴露于高皮质醇血症的影响及其与衰老的关系。因此，我们用神经突方向离散度和密度成像（NODDI）研究了CD患者神经突的变化。
本研究纳入了15例CD患者和15例健康对照者。采用横断面分析检测方向离散度指数（Odi）、神经突密度指数（Ndi）、自由水分数（f）、细胞外水分数（f）。
CD患者的NODDI参数有显著改变。其中一些改变与当前年龄相关。此外，在CD患者的小脑发现树突密度增加。
CD患者多个区域的高皮质醇血症导致的树突密度相对降低与当前年龄相关。我们的研究增进了对衰老与GC之间联系的理解。
