Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Sci Rep. 2020 Mar 13;10(1):4656. doi: 10.1038/s41598-020-61475-4.
Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (the principal mediators of atherosclerosis). Despite this, aggressive endothelial repair (progressing atherosclerosis) might cause a wasting reduction in CD34+ cells, which could result in a lower capacity of endothelial repair and hypertension. As yet, no prospective study has clarified the association of circulating CD34+ cells with active arterial wall thickening. We conducted a prospective study of 363 men aged 60-69 years who participated in a general health check-up at least twice from 2014-2017. The circulating CD34+ cell count was significantly positively associated with active arterial wall thickening among subjects without hypertension (n = 236), but not among subjects with hypertension (n = 127). The fully adjusted odds ratios (ORs) of active arterial wall thickening for the logarithmic circulating CD34+ cell count were 1.83 (1.19, 2.84) and 0.69 (0.36, 1.32) for subjects without and with hypertension, respectively. Circulating CD34+ cells are positively associated with active arterial wall thickening in subjects without hypertension. This study demonstrates a means to clarify the mechanisms of endothelial repair in elderly subjects.
与年龄相关的身体变化，如低度炎症和氧化应激增加，通过刺激 CD34+细胞的产生，诱导内皮修复并导致动脉壁的活跃增厚（动脉粥样硬化的主要介导物）。尽管如此，积极的内皮修复（进展中的动脉粥样硬化）可能会导致 CD34+细胞的消耗减少，这可能导致内皮修复能力降低和高血压。到目前为止，还没有前瞻性研究阐明循环 CD34+细胞与活跃的动脉壁增厚之间的关系。我们对 363 名年龄在 60-69 岁的男性进行了一项前瞻性研究，这些男性在 2014-2017 年期间至少进行了两次常规健康检查。在没有高血压的受试者（n=236）中，循环 CD34+细胞计数与活跃的动脉壁增厚显著正相关，但在有高血压的受试者（n=127）中则没有。对于没有高血压的受试者，活跃的动脉壁增厚的对数循环 CD34+细胞计数的完全调整比值比（OR）分别为 1.83（1.19，2.84）和 0.69（0.36，1.32）。循环 CD34+细胞与无高血压受试者的活跃动脉壁增厚呈正相关。本研究阐明了老年受试者内皮修复机制的一种方法。
