Shimizu Yuji, Sato Shimpei, Koyamatsu Jun, Yamanashi Hirotomo, Nagayoshi Mako, Kadota Koichiro, Maeda Takahiro
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan.
Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Oncotarget. 2016 Jul 19;7(29):44919-44926. doi: 10.18632/oncotarget.10229.
Platelets and circulating CD34-positive cells have been reported to contribute to vascular repair (endothelial repair and developing atherosclerosis). And because hypertension is known to be a strong vascular impairment factors, it should also influence the respective numbers of these factors. To clarify the clinical importance of platelets on vascular repair, we conducted a cross-sectional study of 567 Japanese men aged 60-69 who underwent an annual health check-up between 2013 and 2015. Multiple linear regression analysis of non-hypertensive subjects adjusting for classical cardiovascular risk factors showed that although platelet count did not significantly correlate with carotid intima media thickness (β = -0.05, p = 0.356), it did positively correlate significantly with the natural log of the number of circulating CD34-positive cells (β = 0.26, p < 0.001). In hypertensive subjects, a significant positive correlation was seen between platelets and intima media thickness (β = 0.19, p = 0.008), whereas no significant correlation was seen between platelet count and the natural log of the number of circulating CD34-positive cells (β = 0.11, p = 0.119). Our results indicate that platelet count is an indicator of vascular repair activity (endothelial repair and developing atherosclerosis). Additionally, hypertension might mask the beneficial effects of circulating CD34-positive cells.
据报道，血小板和循环中的CD34阳性细胞有助于血管修复（内皮修复和动脉粥样硬化发展）。而且由于高血压是已知的一种强烈的血管损伤因素，它也应该会影响这些因素的各自数量。为了阐明血小板在血管修复中的临床重要性，我们对2013年至2015年间接受年度健康检查的567名60 - 69岁日本男性进行了一项横断面研究。对非高血压受试者进行经典心血管危险因素校正后的多元线性回归分析表明，虽然血小板计数与颈动脉内膜中层厚度无显著相关性（β = -0.05，p = 0.356），但它与循环中CD34阳性细胞数量的自然对数呈显著正相关（β = 0.26，p < 0.001）。在高血压受试者中，血小板与内膜中层厚度之间存在显著正相关（β = 0.19，p = 0.008），而血小板计数与循环中CD34阳性细胞数量的自然对数之间无显著相关性（β = 0.11，p = 0.119）。我们的结果表明，血小板计数是血管修复活性（内皮修复和动脉粥样硬化发展）的一个指标。此外，高血压可能会掩盖循环中CD34阳性细胞的有益作用。
