Jørgensen Rasmus Møller, Bruun Jens Meldgaard, Kremke Britta, Bahnsen Rikke Frederiksen, Nielsen Bent Windelborg, Vestergaard Esben Thyssen
Department of Pediatrics, Randers Regional Hospital, Skovlyvej 15, 8930, Randers NE, Denmark.
Department of Internal Medicine, Randers Regional Hospital, Randers NE, Denmark.
Eat Weight Disord. 2021 Mar;26(2):537-545. doi: 10.1007/s40519-020-00887-7. Epub 2020 Mar 13.
Childhood obesity has psychological consequences and increases the risk of continuous obesity into adulthood, associated with development of non-communicable disease (e.g. type 2 diabetes). Short-term weight loss intervention studies show good results but long-term studies are limited.
One hundred ninety-nine obese children (4-18 years of age), with a BMI-SDS (standard deviation score) above + 2 SDS were enrolled into a multifactorial family-centered lifestyle intervention study. The children had yearly visits in the outpatient clinic for anthropometrics, blood samples and DXA-scans, and 6-8 meeting with community health workers between these visits. The children followed the intervention up to 3 years.
After a follow-up of 26.7 ± 17.5 months a reduction in BMI-SDS of - 0.25 SDS (p < 0.001) was observed. The 57 children who were adherent to the intervention for ≥ 2 years had significantly reduced BMI-SDS compared to the 142 children with shorter intervention (BMI-SDS: - 0.38 ± 0.67 vs. - 0.20 ± 0.50, p = 0.036). All weight loss was accompanied by decrease in fat mass and increase in muscle mass (p < 0.001).
The intervention was found to induce long-term reduction in BMI-SDS in obese children, with beneficial change in body composition. Children who followed the intervention the longest had the greatest reduction in BMI-SDS.
Level III, longitudinal cohort study.
儿童肥胖具有心理影响，并增加成年后持续肥胖的风险，这与非传染性疾病（如2型糖尿病）的发生有关。短期体重减轻干预研究显示出良好的效果，但长期研究有限。
199名肥胖儿童（4至18岁），BMI-SDS（标准差评分）高于+2 SDS，被纳入一项多因素家庭为中心的生活方式干预研究。这些儿童每年在门诊进行人体测量、血液样本采集和双能X线吸收法扫描，并在这些就诊期间与社区卫生工作者进行6至8次会面。儿童接受干预长达3年。
随访26.7±17.5个月后，观察到BMI-SDS降低了-0.25 SDS（p<0.001）。与142名干预时间较短的儿童相比，57名坚持干预≥2年的儿童BMI-SDS显著降低（BMI-SDS：-0.38±0.67 vs. -0.20±0.50，p=0.036）。所有体重减轻均伴随着脂肪量减少和肌肉量增加（p<0.001）。
该干预措施可使肥胖儿童的BMI-SDS长期降低，并使身体成分发生有益变化。干预时间最长的儿童BMI-SDS降低幅度最大。
III级，纵向队列研究。
