Siegrist Monika, Heitkamp Melanie, Braun Isabell, Vogg Nicolas, Haller Bernhard, Langhof Helmut, Koenig Wolfgang, Halle Martin
Department of Prevention and Sports Medicine, School of Medicine, University Hospital 'rechts der Isar', Technical University of Munich, Munich, Germany.
Department of Prevention and Sports Medicine, School of Medicine, University Hospital 'rechts der Isar', Technical University of Munich, Munich, Germany.
Clin Nutr. 2021 Nov;40(11):5648-5654. doi: 10.1016/j.clnu.2021.09.042. Epub 2021 Oct 8.
Data about the influence of short-term lifestyle intervention in children with obesity on long-term follow-up body weight, adipokines and cardiometabolic risk parameters is scarce.
In a subgroup of the LOGIC-trial (Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children), we assessed anthropometry (BMI, BMI-SDS (Standard Deviation Score), adipokines (omentin-1, chemerin, leptin, adiponectin) and cardiometabolic risk parameters, (e.g. hsCRP) in children with overweight/obesity after 4 weeks of lifestyle intervention (n = 156, 14.0 ± 1.8 yrs) and after one year follow-up (n = 50). Data were compared to normal weight children (JuvenTUM school cohort; n = 152, 13.3 ± 0.7 yrs).
Short-term lifestyle intervention was associated with a significant reduction in BMI and BMI-SDS (p < 0.001), with significant reductions in hsCRP, leptin, and chemerin levels, and an increase in adiponectin and omentin-1 levels (p < 0.001 for all). After one year follow-up a significant reduction in BMI and BMI-SDS was observed in children from the LOGIC-trial (p < 0.001). Improvements in adiponectin (p = 0.025) and chemerin levels (p = 0.027) were seen in children with clear weight loss success (BMI-SDS reduction ≥ 0.2), whereas children with no or only mild weight loss success showed an increase in leptin levels (p < 0.001). An increase in omentin-1 levels was observed after 1 year independent of weight change (p < 0.001).
Effects of short-term weight reduction on mean BMI and BMI-SDS persist over one year. Improvements in omentin-1 levels were independent of short-term or long-term weight loss.
ClinicalTrials.gov: LOGIC-trial: NCT01067157, JuvenTUM-trial: NCT00988754.
关于肥胖儿童短期生活方式干预对长期随访体重、脂肪因子和心脏代谢风险参数影响的数据稀缺。
在LOGIC试验（儿童肥胖生活方式干预的长期影响及遗传影响）的一个亚组中，我们评估了超重/肥胖儿童在生活方式干预4周后（n = 156，14.0 ± 1.8岁）和一年随访后（n = 50）的人体测量指标（BMI、BMI标准差评分）、脂肪因子（网膜素-1、趋化素、瘦素、脂联素）和心脏代谢风险参数（如高敏C反应蛋白）。数据与正常体重儿童（JuvenTUM学校队列；n = 152，13.3 ± 0.7岁）进行比较。
短期生活方式干预与BMI和BMI标准差评分显著降低相关（p < 0.001），高敏C反应蛋白、瘦素和趋化素水平显著降低，脂联素和网膜素-1水平升高（所有p < 0.001）。一年随访后，LOGIC试验中的儿童BMI和BMI标准差评分显著降低（p < 0.001）。体重明显减轻成功（BMI标准差评分降低≥0.2）的儿童脂联素（p = 0.025）和趋化素水平有所改善（p = 0.027），而体重没有减轻或仅轻度减轻成功的儿童瘦素水平升高（p < 0.001）。一年后观察到网膜素-1水平升高，与体重变化无关（p < 0.001）。
短期体重减轻对平均BMI和BMI标准差评分的影响持续一年。网膜素-1水平的改善与短期或长期体重减轻无关。
ClinicalTrials.gov：LOGIC试验：NCT01067157，JuvenTUM试验：NCT00988754。
