Exotic and Emerging Avian Viral Diseases Unit, US National Poultry Research Center, US Department of Agriculture, Agricultural Research Service, Athens, GA, USA.
Methods Mol Biol. 2020;2123:83-92. doi: 10.1007/978-1-0716-0346-8_7.
The earliest recorded cases of what was likely high-pathogenicity AIV in poultry were reported in Italy in the 1870s. Avian influenza infection has been recognized in domestic poultry through the modern era of poultry production. Infection of poultry with either low pathogenic (LP) or highly pathogenic (HP) avian influenza viruses (AIVs) can result in substantial economic consequences. Productivity can be reduced directly and indirectly because of disease leading to decreased egg or meat yield, mortality, vaccination costs, and restricted trade. Aquatic birds are the natural hosts for AIV, and infection tends to be subclinical, although some strains of HPAIV can cause losses in domestic ducks. Biosecurity and vaccination are the most common methods of preventing infection of poultry. Approaches to AIV control vary widely, but elimination of the disease in poultry is a common goal. The basics of AIV biology, clinical disease, molecular aspects, and AIV detection are briefly reviewed.
最早有记录的高致病性禽流感病例可能发生在 19 世纪 70 年代的意大利。通过现代家禽生产,人们已经认识到家禽中存在禽流感感染。低致病性(LP)或高致病性(HP)禽流感病毒(AIV)感染家禽可导致重大经济后果。由于疾病导致产蛋或产肉减少、死亡率增加、疫苗接种成本增加和贸易受限,生产力会直接和间接受到影响。水禽是 AIV 的天然宿主,感染通常呈亚临床状态,尽管某些高致病性 AIV 株可导致家鸭死亡。生物安全和疫苗接种是预防家禽感染的最常见方法。AIV 控制方法差异很大,但消灭家禽中的该疾病是一个共同目标。本文简要回顾了 AIV 的生物学基础、临床疾病、分子方面和 AIV 检测。