Health Psychology PhD Program, UNC Charlotte, Charlotte, North Carolina, USA.
Department of Psychological Science, UNC Charlotte, Charlotte, North Carolina, USA.
J Eval Clin Pract. 2020 Oct;26(5):1539-1547. doi: 10.1111/jep.13386. Epub 2020 Mar 14.
Converging and accumulating evidence for the cross-communication among the nervous, immune, and endocrine systems, a field of study known as psychoneuroimmunology, implicates immunological dysfunction as a shared and common mechanism of both mental and physical illness. For example, psychiatric disorders like schizophrenia, bipolar disorder, major depression, and anxiety disorders have higher prevalence rates across a spectrum of autoimmune conditions compared to the general population. Additionally, subclinical immunological abnormalities are observed in a variety of psychiatric conditions, with chronic inflammation most extensively studied in the pathophysiology of depression. These observations blur the historical distinctions between mental and physical illness, yet clinical practice remains fragmented and primarily focused on differentially treating individual symptoms.
Therapeutically targeting inflammation offers translational opportunities for integrating mental and physical healthcare, a key niche of the interdisciplinary field of health psychology.
Utilizing a psychoneuroimmunological lens, health psychologists and clinicians can reconceptualize healthcare through integrative treatment approaches and advocacy for comprehensive policy-level reform at both the individual-level of care as well as community-wide prevention approaches.
神经、免疫和内分泌系统之间相互交流的证据越来越多,这一被称为心理神经免疫学的研究领域表明,免疫功能障碍是精神和身体疾病的共同机制。例如,与普通人群相比,精神障碍,如精神分裂症、双相情感障碍、重度抑郁症和焦虑症,在一系列自身免疫性疾病中的患病率更高。此外,在各种精神疾病中都观察到亚临床免疫异常,在抑郁症的病理生理学中,慢性炎症研究最为广泛。这些观察结果模糊了精神疾病和身体疾病之间的历史区别,但临床实践仍然支离破碎,主要侧重于针对个体症状进行差异化治疗。
针对炎症进行治疗为整合精神和身体健康护理提供了转化机会,这是健康心理学跨学科领域的一个关键利基。
健康心理学家和临床医生可以通过整合治疗方法,并倡导在护理的个体层面以及社区范围的预防方法上进行全面的政策层面改革,从心理神经免疫学的角度重新构想医疗保健。