Soria Virginia, Uribe Javiera, Salvat-Pujol Neus, Palao Diego, Menchón José Manuel, Labad Javier
Servicio de Psiquiatría, Hospital Universitari de Bellvitge. Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España; Departamento de Ciencias Clínicas, Universitat de Barcelona, Barcelona, España; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), España.
Servicio de Psiquiatría, Hospital Universitari de Bellvitge. Instituto de Investigación Biomédica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, España.
Rev Psiquiatr Salud Ment (Engl Ed). 2018 Apr-Jun;11(2):115-124. doi: 10.1016/j.rpsm.2017.07.006. Epub 2017 Oct 6.
The immune system is a key element in the organism's defence system and participates in the maintenance of homeostasis. There is growing interest in the aetiopathogenic and prognostic implications of the immune system in mental disorders, as previous studies suggest the existence of a dysregulation of the immune response and a pro-inflammatory state in patients with mental disorders, as well as an increased prevalence of neuropsychiatric symptoms in patients suffering from autoimmune diseases or receiving immune treatments. This study aims to conduct a narrative review of the scientific literature on the role of Psychoneuroimmunology in mental disorders, with special focus on diagnostic, prognostic and therapeutic issues. The development of this body of knowledge may bring in the future important advances in the vulnerability, aetiopathogenic mechanisms, diagnosis and treatment of some mental disorders.
免疫系统是机体防御系统的关键要素，参与体内稳态的维持。免疫系统在精神障碍中的病因学及预后意义正日益受到关注，因为先前的研究表明，精神障碍患者存在免疫反应失调和促炎状态，同时自身免疫性疾病患者或接受免疫治疗的患者出现神经精神症状的患病率也有所增加。本研究旨在对关于心理神经免疫学在精神障碍中作用的科学文献进行叙述性综述，特别关注诊断、预后和治疗问题。这一知识体系的发展未来可能会在某些精神障碍的易感性、病因发病机制、诊断和治疗方面带来重要进展。
