来自Ford 油麻藤根的卡莎烷和诺卡莎烷二萜。
Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
出版信息
Phytochemistry. 2020 Jun;174:112343. doi: 10.1016/j.phytochem.2020.112343. Epub 2020 Mar 13.
Detailed phytochemical investigation of the roots of Erythrophleum fordii furnished seven undescribed cassane-type diterpenoids, erythrocassanoids A-E and erythro-norcassanoids A, B and two known clerodane diterpenes, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid. Their structures were determined by 1D, 2D NMR and HRESIMS analysis. The antiviral activities of these compounds were evaluated. Among them, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid showed antiviral activities against influenza virus and coxsackie virus with IC values ranging from 11.11 to 29.60 μM.
对黔桂鹅掌柴根的详细植物化学研究提供了七个未描述的卡烷型二萜，即 erythrocassanoids A-E 和 erythro-norcassanoids A、B，以及两个已知的 clerodane 二萜，15-羟基-3- cleroden-2-one 和 2-氧代 populifolic 酸甲酯。它们的结构通过 1D、2D NMR 和 HRESIMS 分析确定。评估了这些化合物的抗病毒活性。其中，15-羟基-3- cleroden-2-one 和 2-氧代 populifolic 酸甲酯对流感病毒和柯萨奇病毒具有抗病毒活性，IC 值范围为 11.11 至 29.60 μM。
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