Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Center of Experimental and Molecular Medicine & Division of Infectious Diseases, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, the Netherlands.
Department of Pediatrics, Pediatric Hematology/Oncology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794-8111, USA.
Crit Care Clin. 2020 Apr;36(2):233-253. doi: 10.1016/j.ccc.2019.11.002. Epub 2020 Feb 5.
In sepsis, coagulation is activated and there is an increased risk of developing a consumptive coagulopathy with attendant increase in mortality. The processes that regulate hemostasis evolved as a component of the inflammatory response to infection. Many points of interaction occur on the endothelial cell surface linking the 2 cell types in the initiation and regulation of hemostasis and inflammation. Consequently, inflammation stimulates both platelets and endothelial cells in ways that affect both hemostasis and the immune response. Platelets are also prime drivers of the inflammatory response. This article discusses the pathways wherein inflammation regulates platelet and endothelial cell function.
在脓毒症中，凝血被激活，并且发生消耗性凝血病的风险增加，从而导致死亡率增加。调节止血的过程是作为感染时炎症反应的一部分而进化的。在启动和调节止血和炎症过程中，许多相互作用点发生在内皮细胞表面上，将这 2 种细胞类型联系起来。因此，炎症以影响止血和免疫反应的方式刺激血小板和内皮细胞。血小板也是炎症反应的主要驱动因素。本文讨论了炎症调节血小板和内皮细胞功能的途径。
