Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Friedrich Schiller University, Lessingstraße 8, Jena, 07743, Germany; JeNaCell GmbH, Göschwitzer Str. 22, 07745, Jena, Germany.
Nutritional Biochemistry and Physiology, Institute of Nutritional Sciences, Friedrich Schiller University, Dornburger Straße 25, 07743, Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Friedrich Schiller University, Dornburger Straße 25, 07743, Jena, Germany.
Carbohydr Polym. 2020 May 15;236:116062. doi: 10.1016/j.carbpol.2020.116062. Epub 2020 Feb 22.
Bacterial cellulose (BC) has proven its high potential as active wound dressing and drug delivery system in many scientific studies, but the transferability of the methods to efficient manufacturing still needs to be demonstrated. This study presents a technically feasible, straightforward and efficient approach to modify BC according to specific medical requirements, to scale-up the cultivation and to load the active pharmaceutical ingredient of interest. By means of in situ-modification of the network structure using water-soluble poly(ethylene glycol) 400 and 4000 on pilot-scale, up to 41.5 ± 3.0 % higher transparency of the dressing, 40.6 ± 3.8 % increased loading capacity and 9% increased total release of the anti-inflammatory model drug diclofenac sodium could be obtained. Spray loading was investigated as material efficient alternative to absorption loading allowing a significant reduction in loading time.
细菌纤维素（BC）已在许多科学研究中证明了其作为活性伤口敷料和药物输送系统的高潜力，但仍需要证明这些方法在高效制造中的可转移性。本研究提出了一种技术上可行、直接有效的方法，根据特定的医疗需求对 BC 进行改性，扩大培养规模并负载有治疗作用的药物成分。通过在中试规模上使用水溶性聚乙二醇 400 和 4000 原位修饰网络结构，敷料的透明度可提高 41.5±3.0%，载药量可提高 40.6±3.8%，抗炎模型药物双氯芬酸钠的总释放量可提高 9%。喷雾负载被研究为一种更有效的替代吸收负载的方法，显著缩短了负载时间。
