Zahel Paul, Beekmann Uwe, Eberlein Thomas, Schmitz Michael, Werz Oliver, Kralisch Dana
JeNaCell GmbH-An Evonik Company, 07745 Jena, Germany.
Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany.
Pharmaceuticals (Basel). 2022 May 30;15(6):683. doi: 10.3390/ph15060683.
Modern wound treatment calls for hydroactive dressings. Among the variety of materials that have entered the field of wound care in recent years, the carbohydrate polymer bacterial cellulose (BC) represents one of the most promising candidates as the biomaterial features a high moisture-loading and donation capacity, mechanical stability, moldability, and breathability. Although BC has already gained increasing relevance in the treatment of burn wounds, its potential and clinical performance for "chronic wound" indications have not yet been sufficiently investigated. This article focuses on experimental and clinical data regarding the application of BC within the indications of chronic, non-healing wounds, especially venous and diabetic ulcers. A recent clinical observation study in a chronic wound setting clearly demonstrated its wound-cleansing properties and ability to induce healing in stalling wounds. Furthermore, the material parameters of BC dressings obtained through the static cultivation of were investigated for the first time in standardized tests and compared to various advanced wound-care products. Surprisingly, a free swell absorptive capacity of a BC dressing variant containing 97% moisture was found, which was higher than that of alginate or even hydrofiber dressings. We hypothesize that the fine-structured, open porous network and the resulting capillary forces are among the main reasons for this unexpected result.
现代伤口治疗需要水活性敷料。近年来，在进入伤口护理领域的各种材料中，碳水化合物聚合物细菌纤维素（BC）作为一种生物材料，因其具有高水分负载和供给能力、机械稳定性、可模塑性和透气性等特点，成为最有前景的候选材料之一。尽管BC在烧伤创面治疗中已越来越受关注，但其在“慢性伤口”适应症方面的潜力和临床性能尚未得到充分研究。本文重点关注BC在慢性、不愈合伤口适应症（尤其是静脉性溃疡和糖尿病溃疡）中的应用的实验和临床数据。最近一项针对慢性伤口环境的临床观察研究清楚地证明了其伤口清洁特性以及促使停滞伤口愈合的能力。此外，首次在标准化测试中研究了通过静态培养获得的BC敷料的材料参数，并与各种先进的伤口护理产品进行了比较。令人惊讶的是，发现一种含水量为97%的BC敷料变体的自由膨胀吸收能力高于藻酸盐甚至水凝胶敷料。我们推测，精细结构的开放多孔网络以及由此产生的毛细作用力是导致这一意外结果的主要原因之一。
