壳聚糖-纤维素水凝胶与 L-组氨酸和氧化锌纳米粒子缀合用于药物的持续释放：动力学和体外生物学研究。
Chitosan-cellulose hydrogel conjugated with L-histidine and zinc oxide nanoparticles for sustained drug delivery: Kinetics and in-vitro biological studies.
机构信息
Department of Chemical Engineering, National Institute of Technology, Tiruchirapalli, 620015, Tamilnadu, India.
Department of Chemical Engineering, National Institute of Technology, Tiruchirapalli, 620015, Tamilnadu, India.
出版信息
Carbohydr Polym. 2020 May 15;236:116101. doi: 10.1016/j.carbpol.2020.116101. Epub 2020 Feb 29.
Functionalised nanohybrid hydrogel using L-Histidine (HIS) conjugated chitosan, phyto-synthesised zinc oxide nanoparticles (ZNPs) and dialdehyde cellulose (DAC) was formulated as a sustained drug delivery carrier for the polyphenol drugs - Naringenin (NRG), Quercetin (QE) and Curcumin (CUR). A maximum loading efficiency of 90.55 %, 92.84 % and 89.89 %, respectively were optimised for NRG, QE and CUR in the hybrid hydrogel. The maximum drug release was favoured for the optimum drug loading and at pH-5. HIS-chitosan conjugation stabilised the hydrogel and enabled a sustained drug delivery. Drug release kinetics predicted a non-Fickian diffusion-based mechanism along with polymer erosion. Prominent antimicrobial activity against Staphylococcus aureus and Trichophyton rubrum strains were predicted to evolve based on the synergic formulation. Significant biocompatibility towards L929 cells revealed their support for normal cell survival. Anticancer studies towards A431 cells exhibited excellent cytotoxicity with a 15 to 30-fold increase using the hybrid carrier, compared to the free polyphenol drugs.
采用 L-组氨酸（HIS）修饰壳聚糖、植物合成氧化锌纳米粒子（ZNPs）和二醛纤维素（DAC）的功能化纳米杂化水凝胶被设计为多酚药物 - 柚皮苷（NRG）、槲皮素（QE）和姜黄素（CUR）的缓释药物载体。在杂化水凝胶中，NRG、QE 和 CUR 的最大负载效率分别优化为 90.55%、92.84%和 89.89%。在最佳药物负载和 pH-5 下有利于最大药物释放。HIS-壳聚糖缀合稳定了水凝胶并实现了药物的持续释放。药物释放动力学预测了基于非 Fickian 扩散机制以及聚合物侵蚀的药物释放。基于协同配方，预计会产生针对金黄色葡萄球菌和红色毛癣菌菌株的显著抗菌活性。对 L929 细胞的显著生物相容性表明它们支持正常细胞存活。与游离多酚药物相比，针对 A431 细胞的抗癌研究显示，使用杂化载体可使细胞毒性提高 15 至 30 倍。
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