Bazarova E N, Efuni S S, Polianskaia I S, Fedoseeva G I, Okeanova T A
Probl Endokrinol (Mosk). 1988 Sep-Oct;34(5):14-6.
A total of 18 patients with Hashimoto's thyroiditis aged 20 to 57 were examined (16 females and 2 males). The control group included 267 healthy donors. Antigens of A, B, C and D loci of the HLA system were determined in all the patients. HLA Dr3 was determined in 14 (77.8%) of 18 patients (p less than 0.01). The relative disease risk in carriers of this antigen was 12.6. At the same time a 6-fold decrease in the frequency of HLA Dr2 was found in the patients. The authors discussed the problem of the predisposing role of HLA Dr3 in the development of autoimmune diseases and of the "protective" properties of HLA Dr2.
共检查了18例年龄在20至57岁之间的桥本甲状腺炎患者（16名女性和2名男性）。对照组包括267名健康供者。对所有患者测定了HLA系统A、B、C和D位点的抗原。18例患者中有14例（77.8%）检测到HLA Dr3（p<0.01）。该抗原携带者的相对疾病风险为12.6。同时发现患者中HLA Dr2的频率下降了6倍。作者讨论了HLA Dr3在自身免疫性疾病发生中的易患作用问题以及HLA Dr2的“保护”特性问题。
