Marchiori Luciana L M, Dias Ana C M, Gonçalvez Alyne S, Poly-Frederico Regina C, Doi Marcelo Y
Centre of Biological and Health Sciences (CCBS), University of Northern Paraná (UNOPAR), Londrina, PR, Brazil.
Research Centre in Health Sciences (CPCS), University of Northern Paraná (UNOPAR), Londrina, PR, Brazil.
Noise Health. 2018 Mar-Apr;20(93):37-41. doi: 10.4103/nah.NAH_34_17.
Tinnitus is a common disorder that occurs frequently across all strata of population and has an important health concern and is often associated with different forms of the hearing loss of varying severity.
To investigate the association between the polymorphism of tumor necrosis factor alpha (TNFα) in the region -308 G/A with the susceptibility to tinnitus in individuals with the history of exposure to occupational noise.
This was a cross-sectional study with a sample of 179 independent elderly people above 60 years of age.
Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through polymerase chain reaction by restriction fragment length polymorphism.
Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%.
Among elderly with tinnitus (43.01%), 33.76% had a history of exposure to occupational noise. A statistically significant association was found between genotype frequencies of the TNFα gene in the -308 G/A region and the complaint of tinnitus (P = 0.04 and χ = 4.19). The elderly with the G allele were less likely to have tinnitus due to occupational noise exposure when compared to those carrying the A allele (OR = 2.74; 95% CI: 1.56-4.81; P < 0.0005).
This study suggests an association between the TNFα with susceptibility to tinnitus in individuals with a history of exposure to occupational noise.
耳鸣是一种常见疾病，在所有人群阶层中均频繁发生，是一个重要的健康问题，且常与不同程度的各种听力损失相关。
研究肿瘤坏死因子α（TNFα）基因-308 G/A区域多态性与有职业噪声暴露史个体患耳鸣易感性之间的关联。
这是一项横断面研究，样本为179名60岁以上的独立老年人。
通过访谈获取职业噪声暴露信息。使用纯音听力测定法进行听力学评估，并通过聚合酶链反应-限制性片段长度多态性进行基因分型。
使用卡方检验和比值比（OR）分析数据，显著性水平设定为5%。
在耳鸣老年人中（43.01%），33.76%有职业噪声暴露史。发现TNFα基因-308 G/A区域的基因型频率与耳鸣主诉之间存在统计学显著关联（P = 0.04，χ = 4.19）。与携带A等位基因的老年人相比，携带G等位基因的老年人因职业噪声暴露而患耳鸣的可能性较小（OR = 2.74；95%置信区间：1.56 - 4.81；P < 0.0005）。
本研究表明TNFα与有职业噪声暴露史个体患耳鸣的易感性之间存在关联。
