Laboratory of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China.
Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China.
Int J Biol Sci. 2020 Feb 10;16(7):1194-1206. doi: 10.7150/ijbs.40769. eCollection 2020.
Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles of lncRNAs in the regulation of various cellular activities, including metabolic pathways. In this review, we summarize the latest advances regarding the regulatory roles of lncRNAs in cancer metabolism, particularly their roles in mitochondrial function, glucose, glutamine, and lipid metabolism. Moreover, we discuss the clinical application and challenges of targeting lncRNAs in cancer metabolism. Understanding the complex and special behavior of lncRNAs will allow a better depiction of cancer metabolic networks and permit the development of lncRNA-based clinical therapies by targeting cancer metabolism.
代谢重编程是癌症的一个标志。哺乳动物基因组的特征是广泛的转录，产生丰富的非编码 RNA（ncRNA）。长非编码 RNA（lncRNA）是新发现的功能 ncRNA，通过多种机制发挥广泛的调节作用。新兴的研究揭示了 lncRNA 在调节各种细胞活动中的广泛作用，包括代谢途径。在这篇综述中，我们总结了 lncRNA 在癌症代谢中的调节作用的最新进展，特别是它们在线粒体功能、葡萄糖、谷氨酰胺和脂代谢中的作用。此外，我们还讨论了靶向 lncRNA 治疗癌症代谢的临床应用和挑战。了解 lncRNA 的复杂和特殊行为将允许更好地描述癌症代谢网络，并通过靶向癌症代谢开发基于 lncRNA 的临床治疗方法。
