Department of Pathology, Duke University Medical Center, Durham, NC, United States.
Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
Front Immunol. 2020 Feb 26;11:334. doi: 10.3389/fimmu.2020.00334. eCollection 2020.
Flaviviruses consist of significant human pathogens responsible for hundreds of millions of infections each year. Their antigenic relationships generate immune responses that are cross-reactive to multiple flaviviruses and their widespread and overlapping geographical distributions, coupled with increases in vaccination coverage, increase the likelihood of exposure to multiple flaviviruses. Depending on the antigenic properties of the viruses to which a person is exposed, flavivirus cross-reactivity can be beneficial or could promote immune pathologies. In this review we describe our knowledge of the functional immune outcomes that arise from varied flaviviral immune statuses. The cross-reactive antibody and T cell immune responses that are protective versus pathological are also addressed.
黄病毒属包含多种重要的人类病原体，每年导致数亿例感染。其抗原关系产生的免疫反应对多种黄病毒具有交叉反应性，且这些病毒广泛存在且地理分布重叠，再加上疫苗接种覆盖率的增加，增加了接触多种黄病毒的可能性。根据一个人接触的病毒的抗原特性，黄病毒交叉反应性可能是有益的，也可能促进免疫病理。在这篇综述中，我们描述了我们对不同黄病毒免疫状态下产生的功能性免疫结果的了解。还讨论了针对保护性和病理性的交叉反应性抗体和 T 细胞免疫反应。
