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先前存在的黄热病免疫力会损害并调节对蜱传脑炎疫苗接种的抗体反应。

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination.

作者信息

Bradt Victoria, Malafa Stefan, von Braun Amrei, Jarmer Johanna, Tsouchnikas Georgios, Medits Iris, Wanke Kerstin, Karrer Urs, Stiasny Karin, Heinz Franz X

机构信息

1Center for Virology, Medical University of Vienna, Vienna, Austria.

2Division of Infectious Diseases, Department of Medicine, University Hospital of Zurich, Zurich, Switzerland.

出版信息

NPJ Vaccines. 2019 Sep 6;4:38. doi: 10.1038/s41541-019-0133-5. eCollection 2019.

DOI:10.1038/s41541-019-0133-5
PMID:31508246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6731309/
Abstract

Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory ('original antigenic sin'), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus-naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations.

摘要

黄病毒作为节肢动物传播的人类病原体，在全球范围内的影响日益增加，寨卡病毒、登革热病毒、黄热病病毒、西尼罗河病毒、日本脑炎病毒和蜱传脑炎病毒（TBE）都是例证。由于所有黄病毒在抗原性上都相关，它们易于出现免疫记忆现象（“原始抗原罪”），这可在相继感染和/或接种疫苗过程中调节免疫反应。在我们的研究中，我们分析了预先存在的黄热病疫苗衍生免疫对蜱传脑炎疫苗接种抗体反应的影响。通过比较黄热病疫苗接种前个体和未接触过黄病毒个体的样本，我们发现黄热病免疫不仅显著损害了对蜱传脑炎疫苗接种的中和抗体反应，还降低了特异性蜱传脑炎病毒中和活性（NT/ELISA滴度比）。我们的结果表明，预先存在的交叉反应免疫可能对黄病毒疫苗接种结果产生负面影响，这也可能适用于相继的黄病毒感染和/或疫苗接种的其他组合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/bcb0cf8626c6/41541_2019_133_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/16627c05ac6a/41541_2019_133_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/5b372afebe85/41541_2019_133_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/dbf5a7f74989/41541_2019_133_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/35c939343b4f/41541_2019_133_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/22e36807c85c/41541_2019_133_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/5adca6fa97cb/41541_2019_133_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/3fc86e6a3b51/41541_2019_133_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/bcb0cf8626c6/41541_2019_133_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/16627c05ac6a/41541_2019_133_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/5b372afebe85/41541_2019_133_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/dbf5a7f74989/41541_2019_133_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/35c939343b4f/41541_2019_133_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/22e36807c85c/41541_2019_133_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/5adca6fa97cb/41541_2019_133_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/3fc86e6a3b51/41541_2019_133_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a3/6731309/bcb0cf8626c6/41541_2019_133_Fig8_HTML.jpg

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