Rodrigues Junior Luiz Fernando, Mendes Fernanda de Souza Nogueira Sardinha, Pinto Vivian Liane Mattos, da Silva Paula Simplicio, Sperandio da Silva Gilberto Marcelo, Pinheiro Roberta Olmo, de Sousa Andréa Silvestre, Mediano Mauro Felippe Felix
Laboratory of Clinical Research on Chagas Disease, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil.
Care Support Division, Physical Therapy Service, National Institute of Cardiology, Rio de Janeiro, RJ, Brazil.
J Res Med Sci. 2020 Feb 20;25:18. doi: 10.4103/jrms.JRMS_175_18. eCollection 2020.
Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance.
Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons.
Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period.
Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation.
心脏康复对多种心血管疾病具有抗炎作用；然而，对于与促炎失衡相关的恰加斯心肌病，尚未描述这些作用。
10例重度恰加斯心肌病患者参加了为期8个月的心脏康复计划运动训练。在基线、4个月和8个月时，采用酶联免疫吸附测定法测量白细胞介素-1β（IL-1β）、IL-8、IL-10、干扰素γ（IF-γ）、肿瘤坏死因子α（TNF-α）和单核细胞趋化蛋白-1（MCP-1）的血清水平。使用重复测量的单因素方差分析评估运动对细胞因子水平的影响，并采用Bonferroni事后检验进行多重比较。
在观察期内，促炎细胞因子（TNF-α、IL-1β、IL-8、IF-γ和MCP-1）和抗炎细胞因子（IL-10）的水平无显著变化。
运动可能通过抑制这种以持续炎症状态为特征的疾病中促炎细胞因子的产生，使重度恰加斯心肌病患者受益。
