Losada-Garcia Noelia, Rodriguez-Oliva Ivan, Simovic Milica, Bezbradica Dejan I, Palomo Jose M
Department of Biocatalysis, Institute of Catalysis (CSIC), Marie Curie 2, Cantoblanco Campus UAM, Madrid 28049, Spain.
Department of Biochemical Engineering and Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade 11000, Serbia.
ACS Omega. 2020 Feb 27;5(9):4362-4369. doi: 10.1021/acsomega.9b04332. eCollection 2020 Mar 10.
Glycoderivatives are an important class of molecules with enormous relevance in numerous biological phenomena; therefore, they have a key role in the learning, understanding, and assessment of different diseases. Nanotechnology, and in particular the design of new nanomaterials, is one of the areas of greatest interest today. In this case, graphene nanomaterials represent very interesting platforms for studying glycosystems, glyconanomaterials that combine the biomolecular recognition and the characteristics of nanoscale objects in the development of early diagnosis systems, and efficient specific therapeutic modalities. In this mini-review, we discuss some results recently described in the literature on the conjugation of graphene materials and carbohydrates through the selective interaction of glycoenzymes in graphene to create new materials with biosensing applications, the development and application of sugar-graphene composites, and finally biosystems combining the properties of graphene with metallic nanoparticles and sugars for the creation of excellent glyconanomaterials as novel systems for the therapy or diagnosis of important diseases such as cancer or diabetes.
糖衍生物是一类重要的分子，在众多生物现象中具有极大的相关性；因此，它们在不同疾病的研究、理解和评估中起着关键作用。纳米技术，尤其是新型纳米材料的设计，是当今最受关注的领域之一。在这种情况下，石墨烯纳米材料是研究糖系统的非常有趣的平台，糖纳米材料在早期诊断系统的开发中结合了生物分子识别和纳米级物体的特性，以及高效的特异性治疗方式。在这篇综述中，我们讨论了最近文献中描述的一些结果，包括通过石墨烯中糖酶的选择性相互作用将石墨烯材料与碳水化合物共轭以创建具有生物传感应用的新材料、糖-石墨烯复合材料的开发和应用，以及最后将石墨烯与金属纳米颗粒和糖的特性相结合的生物系统，用于创建优异的糖纳米材料，作为治疗或诊断癌症或糖尿病等重要疾病的新型系统。
