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可生物降解高分子材料:合成方法

Biodegradable Polymeric Materials: Synthetic Approach.

作者信息

Panchal Siddhi S, Vasava Dilip V

机构信息

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad 380009, Gujarat, India.

出版信息

ACS Omega. 2020 Feb 25;5(9):4370-4379. doi: 10.1021/acsomega.9b04422. eCollection 2020 Mar 10.

Abstract

Polymeric materials obtained from petroleum resources are nonbiodegradable. Defying degradation, they damage the environment as a result of their ending up in the landfills. Synthesized biodegradable polymeric materials (BPMs) have received increasing interest owing to the difficulty in procuring reproducibility when using natural polymeric materials. Through the modification of natural polymeric materials or materials via chemical, microbiological, enzyme-mediated, and chemo-enzymatic synthesis, a comprehensive range of variegated BPMs can be reaped. Amended natural polymeric materials such as starch, cellulose, and chitin have enhanced properties, while synthetic BPMs such as PLA, PGA, PCL, PDS, and PLGA are explicitly designed to pursue coveted applications in multifarious domains such as whole diagnostics and therapeutics. Synthesized BPMs can be embedded with tailored characteristics to justify the neoteric entails of mankind.

摘要

从石油资源中获取的聚合材料是不可生物降解的。由于它们最终被填埋,无法降解,从而对环境造成破坏。合成的可生物降解聚合材料(BPMs)因其在使用天然聚合材料时难以获得可重复性而受到越来越多的关注。通过化学、微生物、酶介导和化学酶合成对天然聚合材料或材料进行改性,可以获得一系列种类繁多的BPMs。改良后的天然聚合材料,如淀粉、纤维素和几丁质,性能得到了增强,而合成的BPMs,如聚乳酸(PLA)、聚乙醇酸(PGA)、聚己内酯(PCL)、聚对二氧环己酮(PDS)和聚乳酸-羟基乙酸共聚物(PLGA),则被明确设计用于在整个诊断和治疗等多个领域中追求令人垂涎的应用。合成的BPMs可以具备定制的特性,以满足人类的新需求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9556/7066571/e34e52baef20/ao9b04422_0003.jpg

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