DNA 双链断裂的检查点反应。
Checkpoint Responses to DNA Double-Strand Breaks.
机构信息
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02454, USA; email:
Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA; email:
出版信息
Annu Rev Biochem. 2020 Jun 20;89:103-133. doi: 10.1146/annurev-biochem-011520-104722. Epub 2020 Mar 16.
Abstract
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
摘要
细胞在每个细胞周期中都会面临 DNA 损伤。在最具危害性的 DNA 损伤类型中，有 DNA 双链断裂（DSBs），如果未修复或修复不当，可能导致细胞死亡或癌变。为了应对 DNA DSBs，细胞激活了一个复杂的 DNA 损伤检查点（DDC）反应，该反应会使细胞周期停滞，重新编程基因表达，并调动 DNA 修复因子，以防止未修复和断裂的染色体遗传。在这里，我们在 budding yeast 模型系统和哺乳动物中研究了由 DNA DSBs 诱导的 DDC。
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