Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China.
Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.
Aging (Albany NY). 2020 Mar 16;12(6):4778-4793. doi: 10.18632/aging.102872.
A close relationship between age and gut microbiota exists in invertebrates and vertebrates, including humans. Long-living people are a model for studying healthy aging; they also have a distinctive microbiota structure. The relationship between the microbiota of long-living people and aging phenotype remains largely unknown. Herein, the feces of long-living people were transplanted into mice, which were then examined for aging-related indices and beneficial bacteria. Mice transplanted with fecal matter from long-living people (L group) had greater α diversity, more probiotic genera ( and ), and short-chain fatty acid producing genera () than the control group. L group mice also accumulated less lipofuscin and β-galactosidase and had longer intestinal villi. This study indicates the effects that the gut microbiota from long-living people have on healthy aging.
衰老和肠道微生物群之间存在密切关系，这种关系在无脊椎动物和脊椎动物中都存在，包括人类。长寿人群是研究健康衰老的模型；他们也具有独特的微生物群落结构。长寿人群的微生物群落与衰老表型之间的关系在很大程度上仍然未知。在此，我们将长寿人群的粪便移植到小鼠体内，然后检测与衰老相关的指标和有益细菌。与对照组相比，接受长寿人群粪便移植的小鼠（L 组）具有更高的α多样性、更多的益生菌属（和）和产生短链脂肪酸的属（）。L 组小鼠还积累了较少的脂褐素和β-半乳糖苷酶，并且其肠绒毛更长。这项研究表明，长寿人群的肠道微生物群对健康衰老有影响。
