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雌性减数分裂过程中的染色体混合与匹配。

Mixing and Matching Chromosomes during Female Meiosis.

机构信息

Collège de France, PSL Research University, CNRS, Inserm, Center for Interdisciplinary Research in Biology, 75005 Paris, France.

Institut Jacques Monod, UMR7592, 15 rue Hélène Brion, 75013 Paris, France.

出版信息

Cells. 2020 Mar 12;9(3):696. doi: 10.3390/cells9030696.

Abstract

Meiosis is a key event in the manufacturing of an oocyte. During this process, the oocyte creates a set of unique chromosomes by recombining paternal and maternal copies of homologous chromosomes, and by eliminating one set of chromosomes to become haploid. While meiosis is conserved among sexually reproducing eukaryotes, there is a bewildering diversity of strategies among species, and sometimes within sexes of the same species, to achieve proper segregation of chromosomes. Here, we review the very first steps of meiosis in females, when the maternal and paternal copies of each homologous chromosomes have to move, find each other and pair. We explore the similarities and differences observed in , , zebrafish and mouse females.

摘要

减数分裂是卵子制造过程中的一个关键事件。在此过程中,卵子通过重组同源染色体的父本和母本拷贝,并通过消除一组染色体成为单倍体,从而产生一组独特的染色体。尽管减数分裂在有性繁殖的真核生物中是保守的,但在不同物种之间,甚至在同一物种的不同性别之间,实现染色体正确分离的策略存在着令人困惑的多样性。在这里,我们回顾了雌性减数分裂的最初步骤,即每条同源染色体的母本和父本拷贝必须移动、找到彼此并配对。我们探讨了在人类、果蝇和斑马鱼以及小鼠女性中观察到的相似性和差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6223/7140621/c94008996e1a/cells-09-00696-g001.jpg

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