A Novel 65-bp Indel in the Gene Is Associated with Chicken Growth and Carcass Traits.

Golgin subfamily B member 1 () gene encodes the coat protein 1 vesicle inhibiting factor, giantin. Previous study showed that mutations of the gene are associated with dozens of human developmental disorders and diseases. However, the biological function of gene in chicken is still unclear. In this study, we detected a novel 65-bp insertion/deletion (indel) polymorphism in the chicken intron 5. Association of this indel with chicken growth and carcass traits was analyzed in a yellow chicken population. Results showed that this 65-bp indel was significantly associated with chicken body weight ( < 0.05), highly significantly associated with neck weight, abdominal fat weight, abdominal fat percentage and the yellow index b of breast ( < 0.01). Analysis of genetic parameters indicated that "" was the predominant allele. Except for the yellow index b of breast, genotype individuals had the best growth characteristics, by comparison with the genotype and genotype individuals. Moreover, the mRNA expression of was detected in the liver tissue of chicken with different genotypes, where the genotype displayed high expression levels. These findings hinted that the 65-bp indel in could be assigned to a molecular marker in chicken breeding and enhance production in the chicken industry.