Ophthalmology Department, TOBB ETU Medical School, Ankara, Turkey.
Ophthalmology Department, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.
Semin Ophthalmol. 2020 Jan 2;35(1):78-85. doi: 10.1080/08820538.2020.1730916.
: To compare the outcomes of non-invasive break-up time (NI-BUT) test and the other conventional dry eye tests.: The right eyes of 170 subjects were included in the study. In order to evaluate the tear quality of the patients, NI-BUT levels were measured by the Scheimplug-Placido disk system (Sirius topography). Tear osmolarity test was performed with TearLab Osmolarity System. Topical anesthesia-assisted type I Schirmer test and topical anesthesia-assisted BUT were lastly applied to all patients in order not to affect other measurements.: The mean NI-BUT value was 9.59 ± 4.37 sec, tear osmolarity was 292.93 ± 9.30 mOsm/L, Schirmer test was 15.32 ± 6.05 mm/5 min, and biomicroscopic BUT value was 8.98 ± 3.79 sec. The Schirmer test results were statistically significantly correlated with biomicroscopic BUT and NI-BUT values ( = .019, r = 0.180 and = .030, r = 0.166; respectively). It was also found that tear osmolarity was strongly and inversely correlated with biomicroscopic BUT and topographic NI-BUT values ( < .001, r = -0.554 and < .001, r = -0.528; respectively). There was no significant correlation between Schirmer test and tear osmolarity.: It is important to use a sensitive, reproducible and non-invasive method in the evaluation of tear functions. We think that the objective and noninvasive topographic NI-BUT measurements and the minimally invasive osmolarity measurements should be used more frequently in practice because they are correlated with the measurements obtained by invasive methods and should be widespread in clinics.
: 比较非侵入性泪膜破裂时间（NI-BUT）测试与其他常规干眼症测试的结果：研究纳入了 170 名受试者的右眼。为了评估患者的泪液质量，通过 Scheimplug-Placido 盘系统（Sirius topography）测量 NI-BUT 水平。使用 TearLab 渗透压系统进行泪液渗透压测试。最后对所有患者进行局部麻醉辅助的 I 型 Schirmer 测试和局部麻醉辅助 BUT，以避免影响其他测量。：平均 NI-BUT 值为 9.59 ± 4.37 秒，泪液渗透压为 292.93 ± 9.30 mOsm/L，Schirmer 测试值为 15.32 ± 6.05 mm/5 min，生物显微镜 BUT 值为 8.98 ± 3.79 秒。Schirmer 测试结果与生物显微镜 BUT 和 NI-BUT 值呈统计学显著相关（= 0.019，r = 0.180 和= 0.030，r = 0.166；分别）。还发现泪液渗透压与生物显微镜 BUT 和地形图 NI-BUT 值呈强负相关（< 0.001，r = -0.554 和< 0.001，r = -0.528；分别）。Schirmer 测试与泪液渗透压之间无显著相关性。：在评估泪液功能时，使用敏感、可重复和非侵入性的方法很重要。我们认为，客观、非侵入性的地形图 NI-BUT 测量和微创渗透压测量应该在实践中更频繁地使用，因为它们与侵入性方法获得的测量值相关，并且应该在临床中广泛应用。
