Rubyk B I, Fil'chagin N M, Sabadyshin R A
Ter Arkh. 1988;60(9):110-3.
The content of blood lipid peroxidation products was studied in 62 patients with primary degenerative osteoarthrosis. High concentrations of malonic dialdehyde and acylhydroperoxide were revealed in multiple involvement of the joints, in the presence of reactive synovitis, and at the initial stage of disease. Enhanced lipid peroxidation reflected antioxidant deficiency. Antioxidants were recommended for the correction of disturbed lipid peroxidation in degenerative osteoarthrosis. Vitamin E (antioxidant of direct action) at a dose of 100 mg/day as part of multimodality therapy caused a decrease in the blood level of primary and secondary products of lipid peroxidation. Vitamin E was indicated in multiple involvement of the joints and reactive synovitis at the initial stage of degenerative osteoarthrosis.
对62例原发性退行性骨关节炎患者的血脂过氧化产物含量进行了研究。在关节多部位受累、存在反应性滑膜炎以及疾病初期时，发现丙二醛和酰基过氧化氢浓度较高。脂质过氧化增强反映了抗氧化剂缺乏。建议使用抗氧化剂来纠正退行性骨关节炎中脂质过氧化紊乱的情况。作为多模式治疗的一部分，每天服用100毫克剂量的维生素E（直接作用的抗氧化剂）可使脂质过氧化的初级和次级产物的血液水平降低。在退行性骨关节炎初期关节多部位受累和反应性滑膜炎时，建议使用维生素E。
