Department of Public Health and Social Medicine, Medical University of Gdańsk, al. Zwycięstwa 42a, 80-210, Gdańsk, Poland.
"6-10-14 for Health" University Clinical Center, ul. Dębinki 7, 80-952, Gdańsk, Poland.
Lipids Health Dis. 2020 Mar 16;19(1):47. doi: 10.1186/s12944-020-01218-6.
While in the general paediatric population the presence of abnormal lipid values is estimated at 8-20%, depending on the population, accepted norms and age, it was shown that in the population of lean children the prevalence of dyslipidemia is lower than in obese children, in whom it ranges from 20 to over 40%. Until now, however, no results of similar studies on a large sample of children form a Central or Eastern European country have been published. The aim of this study was to evaluate the prevalence of lipid disorders in overweight and obese children and adolescents participating in an integrated weight reduction programme.
According to the "6-10-14 for Health" programme implementation schedule, the programme accepted patients living in Gdańsk, aged 6, 9-11 and 14 years old, with BMI above the 85th percentile for age and sex, according to the Polish percentile charts. During the first visit, each of the participants underwent basic anthropometric examinations - body weight, body height, waist and hip circumference, blood pressure and body composition by bioelectrical impedance were measured. Blood samples were taken to assess lipid, glucose and insulin levels as well as alanine transaminase (ALT) and thyroid stimulating hormone (TSH) activity.
1948 patients underwent full anthropomethric and blood work measurements. At least one of the lipid disorders occurred in 38.23% of girls and 40.51% of boys with overweight and obesity. The most common lipid disorderswere decreased high-density lipoprotein cholesterol (HDL-C) levels (present in 20.55% of the girls and 23.79% of the boys) and elevated low-density lipoprotein cholesterol (LDL-C) (present in 15.31% of the girls and 14.25% of the boys). There was no strong association between lipid disorders and age, sex, birth weight, gestational age at birth or body composition.
Such a frequent occurrence of lipid disorders in the population of children and adolescents should be an important warning signal both at the individual and population level. Not only effective screening methods for overweight and obese children should be implemented from an early age but also therapeutic measures are required.
The trial is registered under the Local Ethics Committee at Medical University of Gdańsk, decision No. NKBBN/228/2012 from 25 June 2012.
在一般儿科人群中，根据人群、公认的标准和年龄，异常脂质值的存在估计为 8-20%。然而，在瘦儿童人群中，血脂异常的患病率低于肥胖儿童，肥胖儿童的患病率从 20%到 40%以上不等。到目前为止，还没有来自中东欧国家的类似大型儿童样本研究结果发表。本研究的目的是评估参与综合减肥计划的超重和肥胖儿童和青少年脂质紊乱的患病率。
根据“6-10-14 为健康”计划的实施时间表，该计划接受了居住在格但斯克的年龄在 6、9-11 和 14 岁的患者，这些患者的 BMI 高于按波兰百分位图表计算的年龄和性别第 85 百分位。在第一次就诊时，每位参与者都接受了基本的人体测量学检查-体重、身高、腰围和臀围、血压和生物电阻抗法测量的身体成分。采集血样以评估血脂、血糖和胰岛素水平以及丙氨酸转氨酶（ALT）和促甲状腺激素（TSH）活性。
1948 名患者接受了完整的人体测量和血液检测。超重和肥胖的女孩和男孩中至少有一种脂质紊乱的发生率分别为 38.23%和 40.51%。最常见的脂质紊乱是高密度脂蛋白胆固醇（HDL-C）水平降低（女孩中为 20.55%，男孩中为 23.79%）和低密度脂蛋白胆固醇（LDL-C）升高（女孩中为 15.31%，男孩中为 14.25%）。脂质紊乱与年龄、性别、出生体重、出生时的胎龄或身体成分之间没有很强的关联。
在儿童和青少年人群中如此频繁地发生脂质紊乱应该是一个重要的个人和群体警告信号。不仅应该从早期开始为超重和肥胖儿童实施有效的筛查方法，而且还需要采取治疗措施。
该试验在格但斯克医科大学地方伦理委员会注册，编号为 NKBBN/228/2012，日期为 2012 年 6 月 25 日。
