脂肪组织的脂肪酸谱可预测成年女性在接受减肥手术后 6 年内的体重和炎症反应。
The fatty acid profile of adipose tissue as a predictor of the ponderal and inflammatory response in adult women six years after bariatric surgery.
机构信息
Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Campus Boa Vista, Vila Velha University, Vila Velha, Espírito Santo, Brazil.
出版信息
Lipids Health Dis. 2020 Mar 16;19(1):45. doi: 10.1186/s12944-020-01229-3.
BACKGROUND
Adipose tissue is involved in several metabolic changes. This study investigated the association between the fatty acid (FA) composition of subcutaneous (SAT) and visceral (VAT) adipose tissue pre-surgery and the postsurgical response regarding the evolution of weight and concentrations of tumour necrosis factor alpha (TNF) and interleukin 6 (IL-6) in adult women who underwent Roux-en-Y gastric bypass (RYGB, n = 14) or sleeve gastrectomy (SG, n = 19) at one (T1), three (T3) and six (T6) years after surgery.
METHODS
Blood samples were collected to obtain plasma for the measurement of IL-6 and TNF. Anthropometric measurements were performed, collecting samples of VAT and SAT during surgery to assess the FA profiles.
RESULTS
Weight loss had a positive correlation with the percentage of VAT-C17:0 (T1, T3) and SAT-C18:2 (T1, T3, T6), and it had a negative correlation with SAT-C22:0 (T1, T3) and VAT-C22:0 (T3). Regarding the inflammatory response, SAT-C14:0 (T6), VAT-C14:0 (T6), SAT-C14:1 (baseline), SAT-C15:0 (T6), SAT-C16:1 (T6), VAT-C16:1 (baseline), SAT-C17:1 (T6), VAT-C17:1 (baseline), VAT-C18:1 (T6), and VAT-C20:1 (T6) exhibited positive correlations with the concentration of IL-6, which were different from the correlations of IL-6 concentrations with SAT-C18:2, VAT-C18:2 (T6), and VAT-C18:3 (T6). The FA SAT-C18:0 (T1) was negatively correlated with TNF concentrations.
CONCLUSIONS
Saturated FAs were predominantly proinflammatory, primarily in the late postoperative period. Alternately, the polyunsaturated FAs exhibited anti-inflammatory potential and predicted weight loss. Thus, the FA profile of the adipose tissue of obese adult women may be a predictor of the ponderal and inflammatory response 6 years after bariatric surgery.
TRIAL REGISTRATION
This study was approved by the ethics committee of Federal University of Viçosa; Registration n. 17287913.2.0000.5153; Date: 07/05/2013.
背景
脂肪组织参与多种代谢变化。本研究调查了手术前皮下（SAT）和内脏（VAT）脂肪组织中脂肪酸（FA）组成与成年女性 Roux-en-Y 胃旁路术（RYGB，n=14）或袖状胃切除术（SG，n=19）后体重和肿瘤坏死因子-α（TNF）和白细胞介素 6（IL-6）浓度变化之间的关系术后 1（T1）、3（T3）和 6（T6）年。
方法
采集血样以获得用于测量 IL-6 和 TNF 的血浆。进行人体测量测量，在手术期间收集 VAT 和 SAT 样本以评估 FA 谱。
结果
体重减轻与 VAT-C17:0（T1、T3）和 SAT-C18:2（T1、T3、T6）的百分比呈正相关，与 SAT-C22:0（T1、T3）和 VAT-C22:0（T3）呈负相关。关于炎症反应，SAT-C14:0（T6）、VAT-C14:0（T6）、SAT-C14:1（基线）、SAT-C15:0（T6）、SAT-C16:1（T6）、VAT-C16:1（基线）、SAT-C17:1（T6）、VAT-C17:1（基线）、VAT-C18:1（T6）和 VAT-C20:1（T6）与 IL-6 浓度呈正相关，这与 SAT-C18:2、VAT-C18:2（T6）和 VAT-C18:3（T6）与 IL-6 浓度的相关性不同。SAT-C18:0（T1）与 TNF 浓度呈负相关。
结论
饱和脂肪酸主要是促炎的，主要在术后晚期。相反，多不饱和脂肪酸具有抗炎潜力，并预测体重减轻。因此，肥胖成年女性脂肪组织的 FA 谱可能是术后 6 年体重和炎症反应的预测指标。
试验注册
本研究经联邦大学 Viçosa 伦理委员会批准；注册号 17287913.2.0000.5153；日期：2013 年 7 月 5 日。
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