Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Phytother Res. 2020 Aug;34(8):2067-2073. doi: 10.1002/ptr.6671. Epub 2020 Mar 16.
Osteoarthritis is the most common articular disease that can lead to chronic pain and severe disability. Curcumin-an effective ingredient in turmeric with anti inflammatory property-plays an important role in protecting the joints against destructive factors. Gingerols and piperine, are the effective ingredients of ginger and black pepper, which may potentially enhance and sustain the effect of curcumin in this direction. To determine the effect of cosupplementation with turmeric extract, black pepper, and ginger on prostaglandin E (PGE ) in patients with chronic knee osteoarthritis, compared with Naproxen. Sixty patients with two different levels of knee osteoarthritis (Grade 2 and 3) were studied. Individuals were randomly assigned to receive daily turmeric extract, ginger, and black pepper together or Naproxen capsule for 4 weeks. PGE was evaluated by ELISA method. 24-hr recall was also assessed. All of participants completed the study. PGE decreased significantly in both groups (p < .001), but there was no significant differences between groups. The results of this study indicated that intake of the selected herbs twice a day for 4 weeks may improve the PGE levels in patients with chronic knee osteoarthritis similar to Naproxen drug.
骨关节炎是最常见的关节疾病，可导致慢性疼痛和严重残疾。姜黄素是姜黄中的一种有效成分，具有抗炎特性，在保护关节免受破坏因素方面起着重要作用。姜辣素和胡椒碱是生姜和黑胡椒的有效成分，它们可能在这方面增强和维持姜黄素的效果。为了确定与萘普生相比，姜黄提取物、黑胡椒和生姜联合补充对慢性膝骨关节炎患者前列腺素 E (PGE ) 的影响。研究了 60 名不同程度膝骨关节炎（2 级和 3 级）的患者。个体被随机分配每天接受姜黄提取物、生姜和黑胡椒联合或萘普生胶囊治疗 4 周。通过 ELISA 法评估 PGE。还评估了 24 小时回忆。所有参与者都完成了研究。两组患者的 PGE 均显著降低（p <.001），但两组之间无显著差异。这项研究的结果表明，每天摄入两次选定的草药，持续 4 周，可能会改善慢性膝骨关节炎患者的 PGE 水平，与萘普生药物相似。
