Rondanelli Mariangela, Riva Antonella, Morazzoni Paolo, Allegrini Pietro, Faliva Milena Anna, Naso Maurizio, Miccono Alessandra, Peroni Gabriella, Degli Agosti Irene, Perna Simone
a Department of Public Health, Experimental and Forensic Medicine, Section of Human Nutri tion and Dietetics, Azienda di Servizialla Persona di Pavia , University of Pavia , Pavia , Italy.
b Research and Development Unit , Indena , Milan , Italy.
Nat Prod Res. 2017 Jun;31(11):1309-1313. doi: 10.1080/14786419.2016.1236097. Epub 2016 Oct 13.
The study aimed to evaluate the effect of Zingiber officinale and Echinacea angustifolia extract supplementation (25 mg of ginger and 5 mg of Echinacea) for 30 days on inflammation and chronic pain in knee osteoarthritis (OA). Consecutive nonsteroidal anti-inflammatory-drugs (NSAIDs) poor responders with chronic inflammation and pain due to knee arthrosis were assessed (15 subjects, age: 67.2 ± 7.9, body mass index: 30.6 ± 7.1, men/women:2/13). The primary endpoint was to determine pain improvement from baseline to Day 30 by Tegner Lysholm Knee Scoring. The secondary endpoints were the assessment of Visual Analog Scale for Pain, health-related quality of life, by the ShortForm36 (SF-36), anthropometric parameters, hydration. After supplementation, a significant improvement of 12.27 points was observed for Lysholm scale score (p < 0.05), SF-36 (p < 0.05), and a decrease in -0.52 cm in knee circumference (left) (p < 0.01). This pilot study provides feasibility and safety data for the use of highly standardised ginger and Echinacea extract supplementation in people with knee OA.
该研究旨在评估连续30天补充25毫克生姜和5毫克紫锥菊提取物对膝骨关节炎（OA）炎症和慢性疼痛的影响。对因膝关节病导致慢性炎症和疼痛且对非甾体抗炎药（NSAIDs）反应不佳的连续患者进行了评估（15名受试者，年龄：67.2±7.9，体重指数：30.6±7.1，男性/女性：2/13）。主要终点是通过Tegner Lysholm膝关节评分法确定从基线到第30天疼痛的改善情况。次要终点是通过视觉模拟疼痛量表、简短健康调查量表（SF-36）评估健康相关生活质量、人体测量参数和水合作用。补充后，Lysholm量表评分显著提高了12.27分（p<0.05），SF-36评分也显著提高（p<0.05），左膝周长减少了0.52厘米（p<0.01）。这项初步研究为在膝骨关节炎患者中使用高度标准化的生姜和紫锥菊提取物补充剂提供了可行性和安全性数据。
