Micelio, Antwerpen, Belgium.
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.
Elife. 2020 Mar 17;9:e52614. doi: 10.7554/eLife.52614.
Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to the FAIR principles of findability, accessibility, interoperability and reusability. Here we describe the breadth and depth of the biomedical knowledge contained within Wikidata, and discuss the open-source tools we have built to add information to Wikidata and to synchronize it with source databases. We also demonstrate several use cases for Wikidata, including the crowdsourced curation of biomedical ontologies, phenotype-based diagnosis of disease, and drug repurposing.
Wikidata 是一个由社区维护的知识库,它由基因组学、蛋白质组学、遗传变异、途径、化学化合物和疾病等领域的知识库中组装而成,并且遵守 FAIR(可发现性、可访问性、互操作性和可重用性)原则。在这里,我们描述了 Wikidata 中包含的生物医学知识的广度和深度,并讨论了我们构建的开源工具,这些工具用于向 Wikidata 添加信息并使其与源数据库同步。我们还展示了 Wikidata 的几个用例,包括生物医学本体的众包策展、基于表型的疾病诊断和药物再利用。