Hoffman William F, Jacobs Merel B, Dennis Laura E, McCready Holly D, Hickok Alex W, Smith Sheehan B, Kohno Milky
Mental Health Division P35C, Veterans Affairs Portland Health Care System, Portland, OR, United States.
Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States.
Front Psychiatry. 2020 Feb 28;11:90. doi: 10.3389/fpsyt.2020.00090. eCollection 2020.
Methamphetamine use and psychopathy are associated with criminal behavior; however, it is unclear how methamphetamine use and psychopathy interact to promote violent, economic and drug offenses. Abnormalities in corticostriatal functional connectivity are exhibited in both psychopathic and methamphetamine dependent individuals, which may contribute to criminal behavior through maladaptive and impulsive decision-making processes. This study shows that psychopathic traits contribute to weaker corticostriatal connectivity in methamphetamine dependence and contributes to an increase in criminal behavior. As the propensity to engage in criminal activity is dependent on a number of factors, a hierarchical regression identifies the contribution of the impulsive antisocial domain of psychopathy, anxiety, years of methamphetamine use and corticostriatal connectivity on different types of criminal offenses. Methamphetamine use and psychopathic traits reduce treatment responsiveness and increase the likelihood of recidivism, and it is therefore important to understand the factors underlying the propensity to engage in criminal behavior.
使用甲基苯丙胺与精神病态均与犯罪行为相关；然而，甲基苯丙胺的使用与精神病态如何相互作用以促成暴力犯罪、经济犯罪和毒品犯罪尚不清楚。精神病态者和甲基苯丙胺依赖者均表现出皮质纹状体功能连接异常，这可能通过适应不良和冲动的决策过程导致犯罪行为。本研究表明，精神病态特质会导致甲基苯丙胺依赖者的皮质纹状体连接减弱，并导致犯罪行为增加。由于从事犯罪活动的倾向取决于多种因素，层次回归分析确定了精神病态的冲动反社会领域、焦虑、甲基苯丙胺使用年限以及皮质纹状体连接对不同类型犯罪的影响。使用甲基苯丙胺和精神病态特质会降低治疗反应性并增加累犯的可能性，因此了解犯罪行为倾向背后的因素非常重要。
