使用期间与缓解期的认知。
Cognition during active methamphetamine use versus remission.
机构信息
Research & Development Service, Veterans Affairs Portland Health Care System, Portland, OR, USA.
Mental Health and Clinical Neurosciences Division, Veterans Affairs Portland Health Care System, Portland, Or, USA.
出版信息
J Clin Exp Neuropsychol. 2021 Aug;43(6):599-610. doi: 10.1080/13803395.2021.1976734. Epub 2021 Oct 6.
Abstract
OBJECTIVE
To evaluate whether cognitive performance in adults with active methamphetamine use (MA-ACT) differs from cognitive performance in adults in remission from MA use disorder (MA-REM) and adults without a history of substance use disorder (CTLs).
METHOD
MA-ACT (n = 36), MA-REM (n = 48), and CTLs (n = 62) completed the Neuropsychological Assessment Battery (NAB).
RESULTS
The MA-ACT group did not perform significantly worse than CTLs on any NAB Index. The MA-REM group performed significantly (p < 0.050) worse than CTLs on the NAB Memory Index. The MA-ACT group performed significantly better than CTLs and the MA-REM group on the Executive Functions Index.
CONCLUSIONS
Some cognitive deficits are apparent during remission from MA use, but not during active use; this may result in clinical challenges for adults attempting to maintain recovery and continue with treatment.
摘要
目的
评估正在使用甲基苯丙胺（MA-ACT）的成年人与从 MA 使用障碍中缓解的成年人（MA-REM）和没有物质使用障碍史的成年人（CTLs）相比，其认知表现是否存在差异。
方法
MA-ACT（n=36）、MA-REM（n=48）和 CTLs（n=62）完成了神经心理评估电池（NAB）。
结果
MA-ACT 组在任何 NAB 指数上的表现均不比 CTLs 差。MA-REM 组在 NAB 记忆指数上的表现明显（p<0.050）比 CTLs 差。MA-ACT 组在执行功能指数上的表现明显优于 CTLs 和 MA-REM 组。
结论
在 MA 使用缓解期间，一些认知缺陷是明显的，但在活跃使用期间则不是；这可能会对试图保持康复并继续治疗的成年人造成临床挑战。
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