Lee Hamilton, Shahrivarkevishahi Arezoo, Lumata Jenica L, Luzuriaga Michael A, Hagge Laurel M, Benjamin Candace E, Brohlin Olivia R, Parish Christopher R, Firouzi Hamid R, Nielsen Steven O, Lumata Lloyd L, Gassensmith Jeremiah J
Department of Chemistry and Biochemistry , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA . Email:
Department of Physics , The University of Texas at Dallas , 800 West Campbell Rd. , Richardson , TX 75080 , USA.
Chem Sci. 2020 Feb 5;11(8):2045-2050. doi: 10.1039/c9sc05510j. eCollection 2020 Feb 28.
Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical . We further overcame the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.
许多用于磁共振成像的造影剂都基于钆，然而副作用限制了它们在一些患者中的使用。有机自由基造影剂（ORCAs）是潜在的替代物，但在生理条件下会迅速还原，并且作为单分子造影剂时弛豫率较低。在此，我们采用了一种超分子策略，其中葫芦[8]脲以纳摩尔亲和力与ORCAs结合，并保护它们免受生物还原剂的影响，从而产生稳定的自由基。我们进一步通过将这种复合物缀合在源自烟草花叶病毒的自组装生物大分子表面，克服了弱造影效果的问题。
