Jiangsu Key Laboratory of Chiral Pharmaceuticals Biosynthesis, Taizhou University, Taizhou, 225300, P. R. China.
Henan Key Laboratory for Creation and Application of New Pesticides, Henan Agricultural University, Zhengzhou, 450002, P. R. China.
Chem Biodivers. 2020 Apr;17(4):e1900674. doi: 10.1002/cbdv.201900674. Epub 2020 Mar 26.
The fruits of Melia toosendan Sieb. et Zucc. (Meliaceae) are a source of bioactive limonoids that can be used as effective pesticides. In this study, two novel limonoids, 6-acetylsendanal and 6-ketocinamodiol, were isolated together with fourteen known compounds, namely four protolimonoids, six trichilin-class limonoids, and four C-seco limonoids. The structures of the new compounds were determined by extensive spectroscopic analyses (HR-ESI-MS, UV, IR, 1D and 2D NMR). The bioassay results revealed that eleven of the extracted limonoids exhibited interesting antifeedant activities against the larvae of Pieris rapae with AFC values in the range of 0.11-1.79 mm. Particularly, mesendanin H, with an AFC value of 0.11 mm, exhibited a higher activity than the positive control toosendanin. Information on new bioactive limonoids may provide further insight into M. toosendan as a source of bioactive components.
桃金娘科川栋属植物川楝（Melia toosendan Sieb. et Zucc.）的果实是生物活性柠檬苦素的来源，可作为有效的杀虫剂。在这项研究中，两种新的柠檬苦素，6-乙酰川栋酮和 6-酮卡莫二醇，与十四种已知化合物一起被分离出来，包括四种原柠檬苦素、六种三萜类柠檬苦素和四种 C-断柠檬苦素。新化合物的结构通过广泛的光谱分析（HR-ESI-MS、UV、IR、1D 和 2D NMR）确定。生物测定结果表明，从提取物中分离得到的 11 种柠檬苦素对菜青虫幼虫表现出有趣的拒食活性，AFC 值在 0.11-1.79mm 范围内。特别是，mesendanin H，AFC 值为 0.11mm，表现出比阳性对照川楝素更高的活性。有关新生物活性柠檬苦素的信息可能为川楝作为生物活性成分的来源提供进一步的了解。
