School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
J Leukoc Biol. 2020 Jul;108(1):339-351. doi: 10.1002/JLB.3MIR0220-270R. Epub 2020 Mar 17.
The complement system is a collection of soluble and membrane-bound proteins that together act as a powerful amplifier of the innate and adaptive immune systems. Although its role in infection is well established, complement is becoming increasingly recognized as a key contributor to sterile inflammation, a chronic inflammatory process often associated with noncommunicable diseases. In this context, damaged tissues release danger signals and trigger complement, which acts on a range of leukocytes to augment and bridge the innate and adaptive immune systems. Given the detrimental effect of chronic inflammation, the complement system is therefore well placed as an anti-inflammatory drug target. In this review, we provide a general outline of the sterile activators, effectors, and targets of the complement system and a series of examples (i.e., hypertension, cancer, allograft transplant rejection, and neuroinflammation) that highlight complement's ability to bridge the 2 arms of the immune system.
补体系统是一组可溶性和膜结合蛋白，它们共同作用，作为先天和适应性免疫系统的强大放大器。尽管其在感染中的作用已得到充分证实，但补体系统正越来越被认为是无菌性炎症的关键贡献者，无菌性炎症是一种常与非传染性疾病相关的慢性炎症过程。在这种情况下，受损组织释放危险信号并触发补体，补体作用于一系列白细胞，增强并桥接先天和适应性免疫系统。鉴于慢性炎症的有害影响，因此补体系统是一种很有前途的抗炎药物靶点。在这篇综述中，我们提供了补体系统的无菌性激活剂、效应物和靶标的一般概述，并提供了一系列例子（即高血压、癌症、同种异体移植排斥和神经炎症），这些例子突出了补体在桥接免疫系统的两个分支方面的能力。
