Cytotoxic T cells meet complement: granzyme K as a new initiator of inflammation.
作者信息
Zhao Junyi, Guo Xing, Liu Wanli, Li Conglei
机构信息
School of Medicine, The Chinese University of Hong Kong, Shenzhen, China.
State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Institute for Immunology, Ministry of Education Key Laboratory of Protein Sciences, Tsinghua University, Beijing, China.
出版信息
Cell Mol Immunol. 2025 Jul;22(7):693-695. doi: 10.1038/s41423-025-01303-9. Epub 2025 May 29.
Abstract
摘要
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本文引用的文献
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Nature. 2025 May;641(8061):211-221. doi: 10.1038/s41586-025-08713-9. Epub 2025 Feb 6.
2
GZMK-expressing CD8 T cells promote recurrent airway inflammatory diseases.表达GZMK的CD8 T细胞会促进复发性气道炎症性疾病。
Nature. 2025 Feb;638(8050):490-498. doi: 10.1038/s41586-024-08395-9. Epub 2025 Jan 15.
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The complement system and human autoimmune diseases.补体系统与人类自身免疫性疾病。
J Autoimmun. 2023 May;137:102979. doi: 10.1016/j.jaut.2022.102979. Epub 2022 Dec 18.
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Intracellular and Extracellular Roles of Granzyme K.颗粒酶 K 的细胞内和细胞外作用。
Front Immunol. 2021 May 4;12:677707. doi: 10.3389/fimmu.2021.677707. eCollection 2021.
5
Complement: Bridging the innate and adaptive immune systems in sterile inflammation.补体：连接固有免疫和适应性免疫系统的桥梁在无菌性炎症中。
J Leukoc Biol. 2020 Jul;108(1):339-351. doi: 10.1002/JLB.3MIR0220-270R. Epub 2020 Mar 17.
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Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing.靶细胞的内吞作用：穿孔素和颗粒酶介导杀伤的重要方式。
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Complement: a key system for immune surveillance and homeostasis.补体：免疫监视和稳态的关键系统。
Nat Immunol. 2010 Sep;11(9):785-97. doi: 10.1038/ni.1923. Epub 2010 Aug 19.
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Functional dissection of the granzyme family: cell death and inflammation.颗粒酶家族的功能剖析：细胞死亡和炎症。
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