Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Team 17, F-75006 Paris, France.
Ophthalmology Department, Necker-Enfants Malades University Hospital, APHP, 75015 Paris, France.
Cells. 2020 Mar 13;9(3):705. doi: 10.3390/cells9030705.
Iron is essential for cell survival and function. It is a transition metal, that could change its oxidation state from Fe to Fe involving an electron transfer, the key of vital functions but also organ dysfunctions. The goal of this review is to illustrate the primordial role of iron and local iron homeostasis in retinal physiology and vision, as well as the pathological consequences of iron excess in animal models of retinal degeneration and in human retinal diseases. We summarize evidence of the potential therapeutic effect of iron chelation in retinal diseases and especially the interest of transferrin, a ubiquitous endogenous iron-binding protein, having the ability to treat or delay degenerative retinal diseases.
铁是细胞存活和功能所必需的。它是一种过渡金属，可以将其氧化态从 Fe 变为 Fe，涉及电子转移，这是生命功能的关键，也是器官功能障碍的关键。本综述的目的是说明铁在视网膜生理学和视觉中的基本作用以及局部铁动态平衡，以及铁过量在视网膜变性动物模型和人类视网膜疾病中的病理后果。我们总结了铁螯合在视网膜疾病中的潜在治疗效果的证据，特别是转铁蛋白的治疗效果，转铁蛋白是一种普遍存在的内源性铁结合蛋白，具有治疗或延缓退行性视网膜疾病的能力。
