Human Nutrition Department, College of Health Sciences, QU-Health, Qatar University, Doha 2713, Qatar.
Sport Science Program; College of Arts and Sciences; Qatar University; Doha 2713, Qatar.
Nutrients. 2020 Mar 14;12(3):771. doi: 10.3390/nu12030771.
Poor glycaemic control is associated with chronic life-threatening complications. This cross-sectional study examined whether there is an association between handgrip strength and glycaemic control among patients with diabetes. Data on 1058 participants aged 40 and older were collected from the National Health and Nutritional Examination Survey (NHANES). Muscle strength was assessed using a handgrip dynamometer, and glycaemic control was assessed using HbA1c. Handgrip strength was presented as age- and gender-specific quartiles, with participants in quartile 1 having the lowest handgrip strength and participants in quartile 4 having the highest handgrip strength. Logistic regression analyses were used to assess the association between handgrip strength and poor glycaemic control among participants with diabetes. Three models, each adjusted to include different variables, were employed. Odds ratio (OR) values revealed no association between handgrip strength and glycaemic control after adjusting for age, gender, and race in model 1. With further adjustment for sedentary activity, income-to-poverty ratio, education, and smoking, patients in quartile 4 of handgrip strength had 0.51 odds of poor glycaemic control (95% CI: 0.27-0.99). However, the reported association above vanished when further adjusted for insulin use (OR = 0.67; 95% CI: 0.35-1.28). In conclusion, findings may indicate an association between glycaemic control and muscle strength. This association may be altered by insulin use; further investigations are required.
血糖控制不佳与慢性危及生命的并发症有关。这项横断面研究检查了糖尿病患者的握力与血糖控制之间是否存在关联。数据来自国家健康和营养检查调查（NHANES），共收集了 1058 名年龄在 40 岁及以上的参与者。肌肉力量使用握力计进行评估，血糖控制使用 HbA1c 进行评估。握力以年龄和性别特异性四分位数表示，四分位数 1 的参与者握力最低，四分位数 4 的参与者握力最高。使用逻辑回归分析评估了糖尿病患者握力与血糖控制不佳之间的关联。使用了三种模型，每种模型都调整了不同的变量。在模型 1 中，调整年龄、性别和种族后，握力与血糖控制之间没有关联。在进一步调整久坐活动、收入贫困比、教育和吸烟后，握力四分位 4 的患者血糖控制不佳的几率为 0.51（95%CI：0.27-0.99）。然而，当进一步调整胰岛素使用时，上述关联消失（OR=0.67；95%CI：0.35-1.28）。总之，研究结果可能表明血糖控制与肌肉力量之间存在关联。这种关联可能会因胰岛素使用而改变，需要进一步研究。
